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ARG1 — IL4

Text-mined interactions from Literome

Witte et al., J Surg Res 2002 : The effect of transforming growth factor beta1 ( TGF-beta1 ), interleukin-4 (IL-4), lipopolysaccharide, and wound fluid on arginase activity was also investigated ... TGF-beta and IL-4 significantly increased arginase activity and protein expression whereas lipopolysaccharide and wound fluid did not affect it
Bronte et al., J Immunol 2003 : Arg1 is induced by IL-4 in freshly isolated MSC or cloned MSC lines, and is therefore up-regulated by activated Th2, but not Th1, cells
Zimmermann et al., J Clin Invest 2003 (Asthma...) : Lung arginase activity and mRNA expression were strongly induced by IL-4 and IL-13, and were differentially dependent on signal transducer and activator of transcription 6
Lindemann et al., Naunyn Schmiedebergs Arch Pharmacol 2003 : Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts ... In conclusion, IL-4 and IL-13 can cause a marked up-regulation of arginase activity in rat airway fibroblasts and these effects can be inhibited by glucocorticoids
Barksdale et al., Surgery 2004 : Although isoproterenol, IL-4 , IL-10, and IL-13 individually induced arginase , significant synergy between the combination of isoproterenol with either TGF-beta or the TH2 cytokines was observed
Gray et al., Gene 2005 : Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta
Erdely et al., Am J Physiol Lung Cell Mol Physiol 2006 : IL-4 and TGF-beta increased arginase activity 16- and 5-fold, respectively ... Unlike its effect in RAW 264.7 cells, IL-4 alone did not increase arginase activity in human alveolar macrophages ( AM ) from healthy volunteers
Bonaparte et al., Glia 2006 (Central Nervous System Viral Diseases) : Further, both constitutive and IL-4/IL-10 induced expression of arginase I correlated with elevated STAT6 nuclear binding activity, decreased NO production, and increased virus replication in motheaten compared to wild type astrocytes
Holán et al., Transplantation 2006 : Rejection of rat skin xenografts, on the contrary to rejection of allografts, was associated with a local high production of Th2 cytokines IL-4 and IL-10, overexpression of arginase genes, strongly enhanced arginase activity and attenuated NO generation in the graft
Lotz et al., Immunology 2007 : Also, IL-4 or IL-13 led to rapid signal transducer and activator of transcription 6 phosphorylation, diminished inducible NO synthase expression, and enhanced the antagonistic arginase 1 activity
Morris et al., Tuberculosis (Edinb) 2009 : Furthermore, pharmacologic inhibition of IL-4 induced arginase activity did not abrogate IL-4 inhibition of IFNgamma+ManLAM induced NO expression
Ellyard et al., J Immunother 2010 (Melanoma, Experimental) : Alternatively activated macrophage possess antitumor cytotoxicity that is induced by IL-4 and mediated by arginase-1
Ye et al., J Biol Chem 2012 : Nrdp1 enhances C/EBPß triggered transcriptional activation of the Arg1 reporter gene in the presence of IL-4 stimulation
Serrat et al., Eur J Immunol 2012 : Deacetylation of C/EBPß is required for IL-4 induced arginase-1 expression in murine macrophages
Zhou et al., Journal of neuroinflammation 2012 : Moreover, IL4 mediated induction of Arg1 and Ym1 is impaired after blocking the TGFß receptor I indicating that IL4 induced microglia alternative activation is dependent on active TGFß signalling
Ferrante et al., Inflammation 2013 : In contrast, Th2 cytokines IL-4 and IL-13 activate macrophages by inducing the expression of arginase-1 and the anti-inflammatory cytokine IL-10 in an IL-4 receptor-a (IL-4Ra) dependent manner
Surace et al., American journal of clinical and experimental immunology 2013 : We demonstrate that although ATRA alone has no effect on the expression or activities of arginase 1, ATRA can dramatically potentiate the induction of arginase 1 by IL-4 ... We demonstrate that low dose LPS can effectively suppress the expression of arginase 1 induced by IL-4 and ATRA
Sanson et al., PloS one 2013 : HDL was able to potentiate the IL-4 induced changes in Arg-1 , and tended to do the same for Fizz-1, while suppressing the expression of inflammatory genes in response to IFN?
Corraliza et al., Biochim Biophys Acta 1997 : Moreover, interleukin 10 which induces arginase in macrophages is able to increase the cAMP dependent protein kinase A activity