◀ Back to TGFB1
TGFB1 — TGFBR2
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
TGFBR2
→
TGFB1
(directlyIncreases, TGFB1 Activity)
Evidence: These proteins signal by stimulating formation of specific heteromeric complexes of type I and type II serine/threonine kinase receptors. The type II receptors are encoded by five known mammalian genes, bind to ligands, and phosphorylate and activate the type I receptors, of which there are seven mammalian members (Fig. 1).
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OpenBEL Selventa BEL large corpus:
TGFBR1
→
Complex of TGFB1-TGFBR1-TGFBR2
(directlyIncreases, TGFB1/TGFBR1/TGFBR2 Activity)
Evidence: TGF-B1 is the most abundant and universally expressed isoform; most studies have either examined or been performed with exogenous TGF-B1. TGF-B is secreted into the extracellular matrix as a latent protein complex bound to a latency- associated protein and one of the four isoforms of latent TGF-B binding protein. Activation of TGF-B, which is required for biologic activity, occurs through poorly understood mechanisms likely involving proteolytic processing of the associated proteins and release ...
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BioCarta ctcf: first multivalent nuclear factor:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
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BioCarta tgf beta signaling pathway:
MADH7 (SMAD7)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, inhibits)
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BioCarta tgf beta signaling pathway:
SMAD2/SARA complex (SAR1A-SMAD2)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
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BioCarta nfkb activation by nontypeable hemophilus influenzae:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta (TGFB1/TGFB2/TGFB3)
(modification, collaborate)
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BioCarta nfkb activation by nontypeable hemophilus influenzae:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta-R1/TGF-beta-R2 complex (TGFBR1-TGFBR2)
(modification, collaborate)
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BioCarta nfkb activation by nontypeable hemophilus influenzae:
TGF-beta (TGFB1/TGFB2/TGFB3)
→
TGF-beta-R1/TGF-beta-R2 complex (TGFBR1-TGFBR2)
(modification, collaborate)
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BioCarta ctcf: first multivalent nuclear factor:
TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1)
→
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
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BioCarta ctcf: first multivalent nuclear factor:
TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1)
→
TGF-beta-R2 (TGFBR2)
(modification, collaborate)
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BioCarta ctcf: first multivalent nuclear factor:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta-R2 (TGFBR2)
(modification, collaborate)
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BioCarta alk in cardiac myocytes:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta (TGFB1/TGFB2/TGFB3)
(modification, collaborate)
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BioCarta alk in cardiac myocytes:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta-R1 (TGFBR1)
(modification, collaborate)
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BioCarta alk in cardiac myocytes:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta-R2 (TGFBR2)
(modification, collaborate)
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BioCarta alk in cardiac myocytes:
TGF-beta (TGFB1/TGFB2/TGFB3)
→
TGF-beta-R2 (TGFBR2)
(modification, collaborate)
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BioCarta tgf beta signaling pathway:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
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BioCarta tgf beta signaling pathway:
MADH7 (SMAD7)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, inhibits)
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BioCarta nfkb activation by nontypeable hemophilus influenzae:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
SMAD3
(modification, activates)
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BioCarta tgf beta signaling pathway:
TAB1 (MAP3K7IP1)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
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BioCarta tgf beta signaling pathway:
NR2C2
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
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BioCarta tgf beta signaling pathway:
TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1)
→
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, collaborate)
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BioCarta tgf beta signaling pathway:
TGF-beta/TGF-beta R1 complex (TGFB1_TGFB2_TGFB3-TGFBR1)
→
TGF-beta-R2 (TGFBR2)
(modification, collaborate)
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BioCarta tgf beta signaling pathway:
TGF-beta/TGF-beta-R1/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
→
TGF-beta-R2 (TGFBR2)
(modification, collaborate)
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KEGG TGF-beta signaling pathway:
TGFB1/TGFB2/TGFB3
→
TGFBR2
(protein-protein, activation)
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KEGG Osteoclast differentiation:
TGFB1/TGFB2
→
TGFBR1/TGFBR2
(protein-protein, activation)
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KEGG MAPK signaling pathway:
TGFB1/TGFB2/TGFB3
→
TGFBR1/TGFBR2
(protein-protein, activation)
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KEGG Pathways in cancer:
TGFB1/TGFB2/TGFB3
→
Complex of TGFBR1-TGFBR2
(protein-protein, activation)
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KEGG Pancreatic cancer:
TGFB1/TGFB2/TGFB3
→
Complex of TGFBR1-TGFBR2
(protein-protein, activation)
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KEGG Chronic myeloid leukemia:
TGFB1/TGFB2/TGFB3
→
Complex of TGFBR1-TGFBR2
(protein-protein, activation)
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KEGG Cytokine-cytokine receptor interaction:
TGFB1
→
Complex of TGFBR1-TGFBR2
(protein-protein, activation)
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NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CK2B complex (TGFBR2-TGFBR1-ACVRL1-CSNK2B-ENG-TGFB1)
→
FKBP12 (FKBP1A)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Lee et al., FASEB J 2009, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CK2B complex (TGFBR2-TGFBR1-ACVRL1-CSNK2B-ENG-TGFB1)
→
CK2B/FKBP12/ALK1 (dimer) complex (FKBP1A-ACVRL1-CSNK2B)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Lee et al., FASEB J 2009, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CK2B complex (TGFBR2-TGFBR1-ACVRL1-CSNK2B-ENG-TGFB1)
→
FKBP12/TGFBR1 (dimer) complex (TGFBR1-FKBP1A)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Lee et al., FASEB J 2009, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CK2B complex (TGFBR2-TGFBR1-ACVRL1-CSNK2B-ENG-TGFB1)
→
TGFB1/TGFBR2/Endoglin (dimer) complex (TGFBR2-ENG-TGFB1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Lee et al., FASEB J 2009, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database ALK1 signaling events:
FKBP12 (FKBP1A)
→
TGFB1/TGFBR2/Endoglin (dimer) complex (TGFBR2-ENG-TGFB1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Lee et al., FASEB J 2009, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database ALK1 signaling events:
CK2B/FKBP12/ALK1 (dimer) complex (FKBP1A-ACVRL1-CSNK2B)
→
TGFB1/TGFBR2/Endoglin (dimer) complex (TGFBR2-ENG-TGFB1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Lee et al., FASEB J 2009, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ALK1 signaling events:
FKBP12/TGFBR1 (dimer) complex (TGFBR1-FKBP1A)
→
TGFB1/TGFBR2/Endoglin (dimer) complex (TGFBR2-ENG-TGFB1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Lee et al., FASEB J 2009, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database TGF-beta receptor signaling:
TGFB family (dimer) (TGFB3/TGFB1)
→
TGFBR2 (dimer) complex (TGFBR2)
(modification, collaborate)
Abreu et al., Nat Cell Biol 2002, Lin et al., Cell 1992, Wrana et al., Cell 1992, Wang et al., Cell 1991, Cheifetz et al., Cell 1987, Moustakas et al., J Biol Chem 1993, López-Casillas et al., Cell 1993, Luo et al., EMBO J 1997, Lawler et al., J Biol Chem 1997
Evidence: mutant phenotype, physical interaction, other species
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NCI Pathway Database TGF-beta receptor signaling:
TGFB family (dimer) (TGFB3/TGFB1)
→
TGFB/TGFBR2/betaglycan complex (TGFBR3-TGFBR2)
(modification, collaborate)
Abreu et al., Nat Cell Biol 2002, Lin et al., Cell 1992, Wrana et al., Cell 1992, Wang et al., Cell 1991, Cheifetz et al., Cell 1987, Moustakas et al., J Biol Chem 1993, López-Casillas et al., Cell 1993, Luo et al., EMBO J 1997, Lawler et al., J Biol Chem 1997
Evidence: mutant phenotype, physical interaction, other species
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NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CK2B complex (TGFBR2-TGFBR1-ACVRL1-CSNK2B-ENG-TGFB1)
→
SMAD1-5-8-active (SMAD1/SMAD9/SMAD5)
(modification, activates)
Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Lee et al., FASEB J 2009
Evidence: mutant phenotype, assay
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CK2B complex (TGFBR2-TGFBR1-ACVRL1-CSNK2B-ENG-TGFB1)
→
SMAD1-5-8 (SMAD1/SMAD9/SMAD5)
(modification, activates)
Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Lee et al., FASEB J 2009
Evidence: mutant phenotype, assay
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NCI Pathway Database ALK1 signaling events:
Caveolin-1 (CAV1)
→
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CAV1 complex (TGFBR2-TGFBR1-ACVRL1-CAV1-ENG-TGFB1)
(modification, collaborate)
Santibanez et al., Cardiovasc Res 2008
Evidence: mutant phenotype, physical interaction
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NCI Pathway Database ALK1 signaling events:
Caveolin-1 (CAV1)
→
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB1)
(modification, collaborate)
Santibanez et al., Cardiovasc Res 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CAV1 complex (TGFBR2-TGFBR1-ACVRL1-CAV1-ENG-TGFB1)
→
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB1)
(modification, collaborate)
Santibanez et al., Cardiovasc Res 2008
Evidence: mutant phenotype, physical interaction
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NCI Pathway Database ALK1 signaling events:
TGFBR2 (dimer) complex (TGFBR2)
→
TGFB1 (dimer) complex (TGFB1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Cheifetz et al., J Biol Chem 1992*, Attisano et al., Cell 1993, Yamashita et al., J Biol Chem 1994*, Barbara et al., J Biol Chem 1999
Evidence: physical interaction
-
NCI Pathway Database ALK1 signaling events:
TGFBR2 (dimer) complex (TGFBR2)
→
TGFB1/TGFBR2/Endoglin (dimer) complex (TGFBR2-ENG-TGFB1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Cheifetz et al., J Biol Chem 1992*, Attisano et al., Cell 1993, Yamashita et al., J Biol Chem 1994*, Barbara et al., J Biol Chem 1999
Evidence: physical interaction
-
NCI Pathway Database ALK1 signaling events:
Endoglin (dimer) complex (ENG)
→
TGFB1/TGFBR2/Endoglin (dimer) complex (TGFBR2-ENG-TGFB1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Cheifetz et al., J Biol Chem 1992*, Attisano et al., Cell 1993, Yamashita et al., J Biol Chem 1994*, Barbara et al., J Biol Chem 1999
Evidence: physical interaction
-
NCI Pathway Database ALK1 signaling events:
TGFB1 (dimer) complex (TGFB1)
→
TGFB1/TGFBR2/Endoglin (dimer) complex (TGFBR2-ENG-TGFB1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Cheifetz et al., J Biol Chem 1992*, Attisano et al., Cell 1993, Yamashita et al., J Biol Chem 1994*, Barbara et al., J Biol Chem 1999
Evidence: physical interaction
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NCI Pathway Database Glypican 1 network:
TGFB family (dimer) (TGFB3/TGFB1)
→
TGFBR2 (dimer) complex (TGFBR2)
(modification, collaborate)
Li et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, other species
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NCI Pathway Database Glypican 1 network:
TGFB family (dimer) (TGFB3/TGFB1)
→
GPC1/TGFB/TGFBR1/TGFBR2 complex (TGFBR1-GPC1-TGFBR2)
(modification, collaborate)
Li et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CAV1 complex (TGFBR2-TGFBR1-ACVRL1-CAV1-ENG-TGFB1)
→
SMAD1-5-8-active (SMAD1/SMAD9/SMAD5)
(modification, activates)
Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Valdimarsdottir et al., BMC cell biology 2006, Santibanez et al., Cardiovasc Res 2008
Evidence: mutant phenotype, assay
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CAV1 complex (TGFBR2-TGFBR1-ACVRL1-CAV1-ENG-TGFB1)
→
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/PPP1CA complex (TGFBR2-TGFBR1-ACVRL1-PPP1CA-ENG-TGFB1)
(modification, activates)
Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Valdimarsdottir et al., BMC cell biology 2006, Santibanez et al., Cardiovasc Res 2008
Evidence: mutant phenotype, assay
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CAV1 complex (TGFBR2-TGFBR1-ACVRL1-CAV1-ENG-TGFB1)
→
SMAD1-5-8 (SMAD1/SMAD9/SMAD5)
(modification, activates)
Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Valdimarsdottir et al., BMC cell biology 2006, Santibanez et al., Cardiovasc Res 2008
Evidence: mutant phenotype, assay
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/PPP1CA complex (TGFBR2-TGFBR1-ACVRL1-PPP1CA-ENG-TGFB1)
→
SMAD1-5-8 (SMAD1/SMAD9/SMAD5)
(modification, inhibits)
Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Valdimarsdottir et al., BMC cell biology 2006, Santibanez et al., Cardiovasc Res 2008
Evidence: mutant phenotype, assay
-
NCI Pathway Database ALK1 signaling events:
PPP1CA (PPP1CA)
→
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/PPP1CA complex (TGFBR2-TGFBR1-ACVRL1-PPP1CA-ENG-TGFB1)
(modification, collaborate)
Valdimarsdottir et al., BMC cell biology 2006
Evidence: physical interaction
-
NCI Pathway Database ALK1 signaling events:
PPP1CA (PPP1CA)
→
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB1)
(modification, collaborate)
Valdimarsdottir et al., BMC cell biology 2006
Evidence: physical interaction
-
NCI Pathway Database ALK1 signaling events:
SMAD7 (SMAD7)
→
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/PPP1CA complex (TGFBR2-TGFBR1-ACVRL1-PPP1CA-ENG-TGFB1)
(modification, activates)
Valdimarsdottir et al., BMC cell biology 2006
Evidence: physical interaction
-
NCI Pathway Database ALK1 signaling events:
SMAD7 (SMAD7)
→
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB1)
(modification, activates)
Valdimarsdottir et al., BMC cell biology 2006
Evidence: physical interaction
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/PPP1CA complex (TGFBR2-TGFBR1-ACVRL1-PPP1CA-ENG-TGFB1)
→
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB1)
(modification, collaborate)
Valdimarsdottir et al., BMC cell biology 2006
Evidence: physical interaction
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB1)
→
FKBP12 (FKBP1A)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB1)
→
FKBP12/TGFBR1 (dimer) complex (TGFBR1-FKBP1A)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB1)
→
FKBP12/ALK1 (dimer) complex (FKBP1A-ACVRL1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ALK1 signaling events:
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB1)
→
TGFB1/TGFBR2/Endoglin (dimer) complex (TGFBR2-ENG-TGFB1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ALK1 signaling events:
FKBP12 (FKBP1A)
→
TGFB1/TGFBR2/Endoglin (dimer) complex (TGFBR2-ENG-TGFB1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ALK1 signaling events:
FKBP12/TGFBR1 (dimer) complex (TGFBR1-FKBP1A)
→
TGFB1/TGFBR2/Endoglin (dimer) complex (TGFBR2-ENG-TGFB1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ALK1 signaling events:
FKBP12/ALK1 (dimer) complex (FKBP1A-ACVRL1)
→
TGFB1/TGFBR2/Endoglin (dimer) complex (TGFBR2-ENG-TGFB1)
(modification, collaborate)
Lux et al., J Biol Chem 1999, Goumans et al., Mol Cell 2003, Blanco et al., J Cell Physiol 2005, Attisano et al., Cell 1993, Wang et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
TGFB1
→
TGFBR2
(indirect_complex)
Wu et al., Science 2000, Tanaka et al., Br J Cancer 2000*, Souchelnytskyi et al., Methods Mol Biol 2001, Wrana et al., Cell 1992, Kang et al., Nat Cell Biol 2008*, Zhang et al., Proc Natl Acad Sci U S A 2009*, Zhang et al., Cell Res 2010*, Goudie et al., Nat Genet 2011*, Fleming et al., Cancer Res 2013, Moustakas et al., J Biol Chem 1993, Wrana et al., Nature 1994, Franzén et al., Cell 1993, Souchelnytskyi et al., EMBO J 1996, Hayashi et al., Cell 1997, Chen et al., EMBO J 1997, Nakao et al., Nature 1997, Tsukazaki et al., Cell 1998, Grady et al., Cancer Res 1999*
-
Reactome Reaction:
TGFB1
→
TGFBR2
(reaction)
Wu et al., Science 2000, Tanaka et al., Br J Cancer 2000*, Souchelnytskyi et al., Methods Mol Biol 2001, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Wrana et al., Cell 1992, Shi et al., J Cell Biol 2004, Kuratomi et al., Biochem J 2005, Wicks et al., Oncogene 2005, Kang et al., Nat Cell Biol 2008*, Zhang et al., Proc Natl Acad Sci U S A 2009*, Zhang et al., Cell Res 2010*, Goudie et al., Nat Genet 2011*, Eichhorn et al., Nat Med 2012, Fleming et al., Cancer Res 2013, Moustakas et al., J Biol Chem 1993, Wrana et al., Nature 1994, Franzén et al., Cell 1993, Souchelnytskyi et al., EMBO J 1996, Chen et al., EMBO J 1997, Grady et al., Cancer Res 1999*
-
WikiPathways MAPK Signaling Pathway:
TGFB2/TGFB1/TGFB3
→
ACVR1C/ACVR1B/TGFBR1/TGFBR2
(activation)
-
WikiPathways TGF-beta Receptor Signaling:
TGFB1/INHBA
→
TGFBR2
(activation)
-
WikiPathways Canonical and Non-Canonical TGF-B signaling:
TGFB1
→
Complex of TGFBR1-TGFBR2
(mim-binding)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
TGFBR2
—
TGFB1
(cross-linking study)
Lin et al., J Biol Chem 1995
-
IRef Biogrid Interaction:
TGFB1
—
TGFBR2
(physical association, affinity chromatography technology)
Attisano et al., Cell 1993
-
IRef Biogrid Interaction:
TGFB1
—
TGFBR2
(physical association, affinity chromatography technology)
Rotzer et al., EMBO J 2001*
-
MIPS CORUM TGF-beta receptor II-TGF-beta1 complex:
TGF-beta receptor II-TGF-beta1 complex complex (TGFB1-TGFBR2)
Zúñiga et al., J Mol Biol 2005*
-
MIPS CORUM TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex:
TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex complex (TGFB1-TGFBR1-TGFBR2)
Zúñiga et al., J Mol Biol 2005*
-
MIPS CORUM TGF-beta-receptor II-TGF-beta1 complex:
TGF-beta-receptor II-TGF-beta1 complex complex (TGFB1-TGFBR2)
Chen et al., J Biol Chem 1994*
-
IRef Corum Interaction:
TGFBR2
—
TGFB1
(association, anti tag coimmunoprecipitation)
Chen et al., J Biol Chem 1994*
-
IRef Corum Interaction:
TGFBR2
—
TGFB1
(association, comigration in non denaturing gel electrophoresis)
Zúñiga et al., J Mol Biol 2005*
-
IRef Corum Interaction:
Complex of TGFBR2-TGFBR1-TGFB1-TGFBR2-TGFBR1-TGFB1-TGFBR1-TGFBR2-TGFB1
(association, anti bait coimmunoprecipitation)
Yamashita et al., J Biol Chem 1994*
-
IRef Dip Interaction:
TGFBR2
—
TGFB1
(direct interaction, coimmunoprecipitation)
Vivien et al., J Biol Chem 1995*
-
IRef Dip Interaction:
TGFBR2
—
TGFB1
(direct interaction, coimmunoprecipitation)
Persson et al., J Biol Chem 1997*
-
IRef Dip Interaction:
TGFBR2
—
TGFB1
(direct interaction, surface plasmon resonance)
Chen et al., Proc Natl Acad Sci U S A 1995*
-
IRef Dip Interaction:
TGFBR2
—
TGFB1
(direct interaction, coimmunoprecipitation)
Wells et al., J Biol Chem 1999*
-
IRef Hprd Interaction:
TGFBR2
—
TGFB1
(in vivo)
Border et al., N Engl J Med 1994*
-
IRef Intact Interaction:
TGFBR2
—
TGFB1
(physical association, anti tag coimmunoprecipitation)
Wu et al., Oncogene 2011*
-
IRef Intact Interaction:
TGFBR2
—
TGFB1
(physical association, surface plasmon resonance)
Tanaka et al., FEBS J 2010
-
IRef Intact Interaction:
TGFBR2
—
TGFB1
(direct interaction, cross-linking study)
Pardali et al., Oncogene 2011*
-
IRef Intact Interaction:
TGFBR2
—
TGFB1
(direct interaction, surface plasmon resonance)
Szláma et al., FEBS J 2010
-
IRef Intact Interaction:
Complex of SCUBE3-TGFB1-TGFBR2
(association, anti tag coimmunoprecipitation)
Wu et al., Oncogene 2011*
-
IRef Ophid Interaction:
TGFBR2
—
TGFB1
(aggregation, confirmational text mining)
Border et al., N Engl J Med 1994*
-
IRef Ophid Interaction:
TGFBR2
—
TGFB1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Kleeff et al., Pancreas 1999
(Pancreatic Neoplasms) :
We conclude that the
TGF-beta 1-induced T beta RII upregulation serves to enhance TGF-beta 1 responsiveness in COLO-357 cells, and that this upregulation
requires the presence of adequate levels of T beta RI and
T beta RII , and a functional Smad4 gene product
Zhao et al., Mol Cell Endocrinol 1999
:
Co-expression with
TbetaRII was
required for binding and cross linking of
TGF-beta1 to TbetaRI deltaK
Ripley et al., Gynecol Oncol 2001
(Endometrial Neoplasms) :
GM-CSF and
TGF-beta1 regulate their own expression and the expression of
TGF-beta type II receptor , which were both upregulated by 17beta-estradiol and medroxyprogesterone acetate treatment and reversed following cotreatment with their respective receptor antagonists
Zieske et al., Invest Ophthalmol Vis Sci 2001
:
To determine the
effect of epidermal growth factor (EGF) and
TGF-beta1 on p15(INK4b) and
TbetaR-I and -II expression, human corneal epithelial cells were grown in culture to 50 % to 60 % confluence, and EGF ( 5 ng/ml ) and/or TGF-beta1 ( 2 ng/ml ) were added for 6 hours ... In cultured cells, EGF and
TGF-beta1 stimulated
TbetaR-II ; however, neither one stimulated TbetaR-I expression
Lindstedt et al., FASEB J 2001
:
In isolated TbetaRI- and
TbetaRII expressing peritoneal macrophages, the activated
TGF-beta1 induces the expression of the plasminogen activator inhibitor 1 ( PAI-1 ), whereas in the mast cells, the levels of TbetaRI, TbetaRII, and PAI-1 expression were below detection
Fernandez et al., J Exp Med 2002
(Plasmacytoma) :
Disruption of the expression of
TGF-beta1 by antisense TGF-beta1 mRNA
restores localization of
TbetaRII at the PCT cell surface, indicating a ligand induced impediment in receptor trafficking
Chen et al., Biochem J 2002
:
In summary, this report demonstrated that acetaldehyde stimulated TGF-beta signalling by increasing the secretion and activation of latent
TGF-beta1 as well as by
inducing the expression of
Tbeta-RII in cultured HSC
Lu et al., Zhonghua Shao Shang Za Zhi 2004
(Cicatrix, Hypertrophic) :
The mRNA expressions of
TGF beta 1 , TGF beta 2 and TGFRI were evidently
increased with decreased mRNA expression of TGF-beta 3 and
TGFR II in the hypertrophic scar when compared with those in the normal skin
Huo et al., Cell Biol Toxicol 2007
(MAP Kinase Signaling System) :
Activation of extracellular signal regulated kinase by
TGF-beta1 via
TbetaRII and Smad7 dependent mechanisms in human bronchial epithelial BEP2D cells
Vásquez et al., J Cell Physiol 2007
:
High D-glucose increases L-arginine transport and eNOS expression following
TbetaRII activation by
TGF-beta1 involving p42/44(mapk) and Smad2 in HUVEC
Zhu et al., Prostate 2008
(Neoplasms, Hormone-Dependent...) :
TGF-beta1 induced transcriptional activity enhanced by DHT in both cell lines (
LNCaP-TbetaRII and PC-3-AR ) via AR-Smad4 interaction
Vega et al., Cardiovasc Res 2009
(Pregnancy Complications) :
hENT1 is down-regulated by
activation of
TbetaRII by
TGF-beta1 in HUVECs, a phenomenon where NO and Sp1 play key roles
Kim et al., J Biol Chem 2009
:
Taken together, our data indicate that
TGF-beta1 induced interaction of TbetaRI and
TbetaRII triggers dissociation of TAK1 from TbetaRI, and subsequently TAK1 is phosphorylated through TAB1 mediated autophosphorylation and not by the receptor kinase activity of TbetaRI
Boudreau et al., J Virol 2009
:
Furthermore, the human Nox4 promoter was responsive to
TGF-beta1 , and the HCV core dependent induction of Nox4 was
blocked by antibody against TGF-beta or the expression of dominant negative
TGF-beta receptor type II
Imamura et al., Atherosclerosis 2010
:
EPCs expressed
TGF-beta receptor type II ( TGF-beta RII ) and
TGF-beta1 induced the phosphorylation of Smad 2 in EPCs
Li et al., J Cell Biochem 2012
:
We thus conclude that miR-17-92 cluster could
inhibit TGFB pathway induced proliferation inhibition and collagen synthesis in PMCs by directly targeting
TGFBR2 , SMAD2, and SMAD4
Inagaki et al., Cell Struct Funct 1994
(Carcinoma, Hepatocellular...) :
We report that TGF-beta 1 protein selectively increased steady-state levels of the mRNA for the serine/threonine kinase receptor 1 ( SKR1 ), a member of the TGF-beta superfamily receptor genes in these cells, whereas
TGF-beta 1 had little effect on expression of the
TGF-beta receptor type II gene
Persson et al., J Biol Chem 1997
:
In the
presence of
TGF-beta1 , TbetaR-I/BMPR-IB and
TbetaR-II/ActR-IIB formed heteromeric complexes with wild-type TbetaR-II and TbetaR-I, respectively, upon stable transfection in mink lung epithelial cell lines
Kleeff et al., J Biol Chem 1998
(Pancreatic Neoplasms) :
The protein synthesis inhibitor cycloheximide ( 10 microg/ml ) completely blocked the
TGF-beta1 mediated
increase in TbetaRI and
TbetaRII expression
Ward et al., Atherosclerosis 1998
(Arterial Occlusive Diseases...) :
Tranilast also prevented the PDGF-BB induced increases in TbetaRII but only partially inhibited the
TGF-beta1 induced upregulation of
TbetaRII
Sarkar et al., Endocrinology 1998
:
Furthermore, the
TGF-beta1 gene-transcription response is less
dependent on
TbetaR-II receptor expression than is the TGF-beta1 growth-inhibitory response