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PTGS2 — TGFB1

Text-mined interactions from Literome

Shao et al., Carcinogenesis 1999 (Colonic Neoplasms...) : TGF-beta1 may regulate COX-2 expression during the colonic adenoma to carcinoma sequence
Fosslien et al., Ann Clin Lab Sci 2000 (Carcinoma, Squamous Cell...) : COX-2 is inducible by oncogenes ras and scr, interleukin-1, hypoxia, benzo [ a ] pyrene, ultraviolet light, epidermal growth factor, transforming growth factor beta , and tumor necrosis factor alpha
Sheng et al., J Biol Chem 2000 : Transforming growth factor-beta1 enhances Ha-ras induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA ... Here we investigated the role of transforming growth factor-beta ( TGF-beta ) in the Ras mediated induction of COX-2 in intestinal epithelial cells ( RIE-1 )
Fong et al., Am J Physiol Lung Cell Mol Physiol 2000 : TGF-beta1 stimulates IL-8 release, COX-2 expression, and PGE ( 2 ) release in human airway smooth muscle cells ... In this study, we tested the ability of transforming growth factor (TGF)-beta1 to stimulate IL-8 release, cyclooxygenase (COX)-2 expression and PGE ( 2 ) generation in cultured human ASM cells and explored the role of COX products and COX-2 induction on IL-8 release
Saha et al., Neoplasia (New York, N.Y.) 1999 : Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells ... In the present studies, we found that transforming growth factor beta1 ( TGF-beta1 ) and epidermal growth factor (EGF) synergistically induced the expression of COX-2 and prostaglandin E2 ( PGE2 ) production in mink lung epithelial ( Mv1Lu ) cells ... The synergistic induction of COX-2 by TGF-beta1 and EGF was not observed in R1B-L17 cells, a line derived from Mv1Lu cells that lacks the TGF-beta type-I receptor ... AG1478, a selective inhibitor of EGF receptor tyrosine kinase activity, completely suppressed the induction of COX-2 expression by either EGF or TGF-beta1+EGF ... Also, PD98059, a specific inhibitor of MEK/ERK pathway, and SB203580, a specific inhibitor of p38 MAPK activity, significantly inhibited the induction of COX-2 in response to combined EGF and TGF-beta1
Roman et al., J Gastrointest Surg 2002 (Colorectal Neoplasms) : Induction of cyclooxygenase-2 and invasiveness by transforming growth factor-beta(1) in immortalized mouse colonocytes expressing oncogenic Ras ... We have investigated whether mouse colonocyte COX-2 levels are regulated by oncogenic Ras or transforming growth factor-beta(1) ( TGF-beta(1) ), and whether these factors also serve to regulate cellular invasiveness ... We found that the induction of COX-2 and eicosanoid release were augmented in the presence of activated Ras and that TGF-beta(1) caused a further increase in COX-2 in the Ras transformed mouse colonocytes
Bradbury et al., Am J Physiol Lung Cell Mol Physiol 2002 (Anoxia...) : Bradykinin, transforming growth factor-beta1 ( TGF-beta1 ), and interleukin-1beta (IL-1beta) increased inducible COX-2 expression and prostaglandin E ( 2 ) ( PGE ( 2 ) ) release
Hiraga et al., Cancer Res 2006 (Bone Neoplasms...) : Stimulation of cyclooxygenase-2 expression by bone derived transforming growth factor-beta enhances bone metastases in breast cancer
Harding et al., Kidney Int 2006 : This study examines the hypothesis that transforming growth factor beta ( TGFbeta ) regulates cyclooxygenase-2 (COX-2) and induces prostaglandin E synthase ( mPGES-1 ) in rat mesangial cells ... The effect of TGFbeta1 on COX-2 gene transcription was assessed using a luciferase reporter assay, and mRNA stability was also determined
Rodríguez-Barbero et al., Kidney Int 2006 : TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells ... However, to date, there are no published data on the possible role of TGF-beta1 in COX-2 expression in human mesangial cells ( HMC ) ... We designed studies to determine ( 1 ) whether TGF-beta1 stimulates COX-2 expression in primary HMC, ( 2 ) whether mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI3K) cascades are involved in TGF-beta1 induced COX-2 expression, and ( 3 ) whether prostaglandin ( PG ) E2 synthesis is affected by TGF-beta1 and MAP kinases and PI3K activation ... TGF-beta1 induces COX-2 promoter activity and COX-2 mRNA and protein expression in HMC ... Extracellular signal regulated kinase ( ERK ) 1/2, p38 MAPK, and PI3K pathway inhibition blunted TGF-beta1 induced COX-2 overexpression ... We demonstrate that TGF-beta1 regulates COX-2 expression in HMC through the activation of ERK1/2, p38 MAPK, and PI3K
Aoki et al., Am J Physiol Cell Physiol 2007 : These data indicate that Smad2/3 dependent pathway plays a central role in COX-2 induction by TGF-beta1 , IL-1beta, and IL-6
Eligini et al., Cardiovasc Res 2007 : TGF-beta1 , either platelet derived or recombinant ( rTGF-beta1 ), induced Cox-2 expression and activity in adherent monocytes at concentrations within the range of those detected in releasates from activated platelets ; this effect was not shared by recombinant platelet derived growth factor ( rPDGFBB )
Liu et al., Am J Respir Cell Mol Biol 2007 : EGFR signaling is required for TGF-beta 1 mediated COX-2 induction in human bronchial epithelial cells ... We studied the regulation of COX-2 expression in immortalized human bronchial epithelial cells ( HBECs ) by transforming growth factor-beta1 ( TGF-beta1 ) and epidermal growth factor (EGF) because these two growth factors are present in both the pulmonary milieu of those at risk for lung cancer as well as in the tumor microenvironment ... EGF significantly enhanced TGF-beta1 mediated induction of COX-2 and corresponding prostaglandin E2 ( PGE2 ) production ... TGF-beta1 and EGF induced COX-2 at the transcriptional and post-transcriptional levels ... EGF receptor (EGFR) inhibition, neutralizing antibody against amphiregulin, or mitogen activated protein kinase kinase ( MEK ) inhibition blocked TGF-beta1 mediated COX-2 induction ... COX-2 induction by TGF-beta1 depended upon Smad3 signaling and required the activity of EGFR or its downstream mediators ... Autocrine amphiregulin signaling maintains EGFR in a constitutively active state in HBECs, allowing for COX-2 induction by TGF-beta1 ... Thus, EGFR ligands, which are abundant in the pulmonary microenvironment of those at risk for lung cancer, potentiate and are required for COX-2 induction by TGF-beta1 in HBEC ... These findings emphasize the central role of EGFR signaling in COX-2 induction by TGF-beta1 and suggest that inhibition of EGFR signaling should be investigated further for lung cancer prevention
Uttamsingh et al., Oncogene 2008 (Cell Transformation, Neoplastic) : Phospholipase C (PLC) and Cox2 induced by EGF plus TGF-beta1 also played a significant role in invasion, whereas PLC was also important for colony formation
Guo et al., Dig Dis Sci 2008 : Synergistic regulation of COX-2 expression by bombesin and transforming growth factor-beta ... BBS, but not TGF-beta1 , stimulated COX-2 promoter activity, and TGF-beta1 enhanced COX-2 mRNA stability through a p38 ( MAPK ) -dependent pathway ... The synergistic regulation of COX-2 expression by TGF-beta1 and BBS may contribute to the upregulation of COX-2 in GI cancers
Matsumura et al., J Biol Chem 2009 : Regulation of transforming growth factor-beta dependent cyclooxygenase-2 expression in fibroblasts
Räsänen et al., J Dermatol Sci 2010 (Neoplasm Metastasis) : TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benign, not in malignant keratinocytes ... TGF-beta1 operates via distinct mechanisms in inducing EMT and metastasis, and supporting this we show that TGF-beta1 induces COX-2 and promotes the migration of benign cells, but does not further augment the migration of malignant cells, indicating their resistance to TGF-beta1 in the context of motility
Roy et al., J Cell Biochem 1996 : Prostaglandin E2, transforming growth factor-beta , and interleukin-1 beta variably regulate the expression of cyclooxygenase 1, cyclooxygenase 2 , and lysyl oxidase in IMR90, human embryo lung fibroblasts
Sheng et al., Cell Growth Differ 1997 : Cyclooxygenase-2 induction and transforming growth factor beta growth inhibition in rat intestinal epithelial cells ... In RIE cells transfected with the COX-2 antisense expression vector ( RIE-AS cells ), TGF-beta 1 induction of COX-2 protein was reduced greater than 90 % ... Taken together, the results demonstrate that TGF-beta 1 strongly induces COX-2 at both the mRNA and protein levels and suggest that this induction of COX-2 is involved in the down-regulation of cyclin D1 and inhibition of cell growth caused by TGF-beta 1 in rat intestinal epithelial cells
Fosslien et al., Ann Clin Lab Sci 1998 (Gastrointestinal Diseases) : COX-2 is highly inducible by endotoxin, IL-1, hypoxia, epidermal growth factor (EGF), benzo [ a ] pyrene, and transforming growth factor beta 1 ( TGF-beta 1 )
Diaz et al., Exp Cell Res 1998 : Analysis of fibroblast proteins showed the induction of cyclooxygenase-1 (Cox-1) by TGF-beta 1 and the induction of Cox-2 by IL-1 beta and TNF-alpha ... TGF-beta 1 alone did not induce Cox-2 transcripts
Takahashi et al., Am J Physiol 1998 (Stomach Ulcer) : In contrast, COX-2 mRNA expression and PGE2 production were promoted by prevention of TGF-beta1 action ... These results indicate that COX-2 protein is highly localized in the base of gastric ulcers in rats and that COX-2 mRNA expression might be regulated positively by IL-1beta and TNF-alpha and negatively by TGF-beta1
Martín-Sanz et al., Br J Pharmacol 1998 : Also, transforming growth factor-beta inhibited the LPS- and pro-inflammatory cytokines dependent expression of COX-2
Levi et al., Biochimie 1998 : On the other hand, COX-2 expression was up-regulated by the macrophage deactivating cytokine TGF-beta 1 , by exogenous PGE2 itself, which acted through EP2 receptors linked to cyclic AMP generation, and by non steroidal anti-inflammatory drugs