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PPARG — PTGS2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PPARG → PTGS2 (increases, PTGS2 Activity)
  Evidence: The sentence (ResnetDB) An activator of peroxisome proliferator-activated receptor gamma, 15-deoxy-Delta(12,14)-prostaglandin J(2), also induces COX-2 expression and inhibits TNFalpha-induced NFkappaB activation and COX-2 expression. is translated to Activation of PTGS2 (Homo sapiens) Gene Expression by PPARG (Homo sapiens) Protein.

Text-mined interactions from Literome

Subbaramaiah et al., J Biol Chem 2001 (Arthritis...) : PMA mediated induction of COX-2 promoter activity was inhibited by PPARgamma ligands ; this suppressive effect was prevented by overexpressing a dominant negative form of PPARgamma or a PPAR response element decoy oligonucleotide
Nixon et al., Prostaglandins Leukot Essent Fatty Acids 2003 (Colorectal Neoplasms) : In general, however, neither COX-1- nor COX-2-specific inhibitors induced the activation of PPARgamma
Li et al., World J Gastroenterol 2003 (Carcinoma, Hepatocellular...) : PPARgamma pathway activation results in apoptosis and COX-2 inhibition in HepG2 cells
Mendez et al., Hypertension 2003 : PPARgamma inhibition of cyclooxygenase-2 , PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes
Han et al., Clin Cancer Res 2003 (Uterine Cervical Neoplasms) : We used transient transfection assays with COX-2 promoter reporter gene constructs to determine the regulatory sites in this promoter, which mediates PPARgamma regulation of COX-2 activity ... Using CaSki cells, we demonstrated that COX-2 and PPARgamma mRNA levels were inversely regulated by PPARgamma ligands in that these compounds up-regulated PPARgamma but down-regulated COX-2 ... The ability of PPARgamma ligands to inhibit COX-2 appears to be mediated predominantly through inhibition of AP-1 protein binding to the CRE site in the COX-2 promoter
Badawi et al., Cancer Res 2004 (Mammary Neoplasms, Experimental) : COX-2 inhibitors and PPAR gamma agonists coordinately mediate their anticancer effect via both COX dependent ( inhibition of COX-2 , activation of PPAR gamma , and modulation PG synthesis ) and COX independent ( induction of proapoptotic factors and inhibition of cell proliferation ) pathways
Sakamoto et al., Br J Cancer 2004 (Adenocarcinoma...) : From these results, it was suggested that PPARgamma activation might suppress COX-2 expression via the nuclear factor-kappaB pathway in the ovarian carcinoma cells and that low expression of PPARgamma and high expression of COX-2 might be involved in carcinogenesis and progression of ovarian tumours
Pawliczak et al., J Biol Chem 2004 : It has been reported that interleukin-8 (IL-8) and cyclooxygenase-2 (COX-2) expression is regulated by peroxisome proliferator activated receptor ( PPAR)-gamma synthetic ligands
Sabichi et al., Cancer Epidemiol Biomarkers Prev 2004 : However, forced expression of PPAR-gamma1 or PPAR-gamma2 in ECs suppressed the high level of endogenous COX-2
Delage et al., Int J Cancer 2005 : HLD consumption induced early downregulation of PPARgamma ( -33.1 % ) and RARbeta ( -53.1 % ) mRNA expression concomitant with an increase in levels of COX-2 ( +45.5 % ) and beta-catenin ( +84.56 % ) and in the number of ACF ( 191.56 +/- 88.60 vs. 21.14 +/- 11.64, p < 0.05 )
Patel et al., Cell Signal 2005 : This work investigates the effects of PPAR(gamma) ligands on the regulation of cyclooxygenase-2 (COX-2) in the human lung epithelial cell line, A549
Sato et al., Shock 2005 (Inflammation...) : Inhibition of COX-2 by NS-398 ( 30 mg/kg, but not 3 or 10 mg/kg ) not only reversed the deleterious effects of COX-2, but additionally induced expression and nuclear translocation of PPARgamma
Yu et al., Hepatology 2006 (Liver Neoplasms...) : Troglitazone mediated PPARgamma activation also suppressed COX-2 expression and induced p27 in HCC cells
Zhang et al., J Invest Dermatol 2006 : We therefore reasoned that PPARgamma activation and PPARgamma dependent COX-2 expression may occur as a general consequence of oxidative stress
Zhang et al., Int Immunopharmacol 2006 (Colitis...) : Treatment with Dex improved PPARgamma expression and inhibited the expression of COX-2 , 15d-PGJ ( 2 ) and PGE ( 2 )
Ptasinska et al., FASEB J 2007 : NO* mediated PPARgamma binding and NO* induction of cyclooxygenase-2 (COX-2) , diacylglycerol (DAG) kinase alpha ( DGKalpha ), and heme oxygenase-1 (HO-1), genes with well characterized PPRE motifs, were cGMP independent
Chêne et al., Biochim Biophys Acta 2007 : These findings demonstrate that n-3 and n-6 PUFA increased PPARgamma activity is necessary for the COX-2 induction in HaCaT human keratinocyte cells
Xin et al., Cancer 2007 (Ascites...) : It was recently reported that high expression of peroxisome proliferator activated receptor gamma ( PPARgamma ) and low expression of cyclooxygenase-2 (COX-2) might be involved in the inhibition of ovarian tumor progression and confirmed that PPARgamma activation could suppress COX-2 expression via the nuclear factor-kappaB pathway in ovarian cancer cells
Bren-Mattison et al., Mol Pharmacol 2008 (Adenocarcinoma...) : Increased PPARgamma inhibited expression of COX-2 protein and promoter activity, resulting in decreased PGE ( 2 ) production
Taketa et al., J Biol Chem 2008 (Atherosclerosis...) : Ox-LDL transiently induced cyclooxygenase-2 (COX-2) mRNA and protein expression, and COX-2 specific inhibition by NS-398 or meloxicam or small interference RNA of COX-2 suppressed Ox-LDL induced PPARalpha and PPARgamma activation
Ulivi et al., J Cell Physiol 2008 (Inflammation) : ( 4 ) p38 is involved in the PPARgamma mediated induction of COX-2
Mustafa et al., Clin Cancer Res 2008 (Adenocarcinoma...) : Both inhibition of COX-2 and activation of PPARgamma can inhibit proliferation of breast cancer cells in vitro
Zhang et al., World J Gastroenterol 2009 (Disease Progression...) : Furthermore, COX-2 inhibition resulted in the up-regulation of PPARgamma expression, a protective molecule with anti-neoplastic effects
Hotta et al., J Lipid Res 2010 : PPARgamma dependent suppression of COX-2 promoter activity was observed in response to carvacrol treatment
Hossain et al., Journal of bioscience and bioengineering 2010 (Mechanotransduction, Cellular) : Compressive force inhibits adipogenesis through COX-2 mediated down-regulation of PPARgamma2 and C/EBPalpha ... In conclusion, compressive force inhibited adipogenesis by suppressing expression of PPARgamma2 and C/EBPalpha in a COX-2 dependent manner
Konger et al., PPAR research 2010 : Importantly, PPARgamma agonist induced COX-2 expression and PGE ( 2 ) production were partially inhibited by the PPARgamma antagonist, GW9662, indicating that both PPARgamma dependent and -independent pathways are likely involved
Rajaram et al., J Immunol 2010 : When activated, PPARgamma promotes IL-8 and cyclooxygenase 2 expression, a process modulated by a PPARgamma agonist or antagonist