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TAB1 — TGFB1

Text-mined interactions from Literome

Zhang et al., Nat Med 2000 (Cardiac Output, Low...) : The transforming-growth-factor-beta activated kinase TAK1 is a member of the mitogen activated protein kinase kinase kinase family, which couples extracellular stimuli to gene transcription
Kawahara et al., J Med Invest 2001 (Atrophy...) : These cells expressed the Toll-like receptor 4 (TLR4) mRNA and its protein, and type I Hp LPS phosphorylated transforming growth factor beta activated kinase 1 ( TAK1 ) and TAK1 binding protein 1 (TAB1) in association with up-regulation of the TLR4 expressions, suggesting that type I Hp LPS evoked distinct TLR4 signaling
Kusumoto et al., Am J Physiol Gastrointest Liver Physiol 2005 : Ecabet completely blocked the LPS triggered phosphorylation of transforming growth factor-beta activated kinase 1 ( TAK1 ) and TAK1 binding protein 1 , activation of caspase 8, loss of mitochondrial membrane potential, release of cytochrome c, activation of caspase 3, and appearance of apoptotic cells
Lim et al., J Mol Cell Cardiol 2005 (Cardiomegaly) : The PKC inhibitors, GO6976 and GF109203X, completely blocked TGF-beta1 induced TAK1 kinase activity and subsequent downstream signaling pathways including ATF-2 phosphorylation, leading to suppression of ATF-2 transcriptional activity
Kim et al., J Biol Chem 2008 : TGF-beta1 stimulation rapidly activates TAK1 in a biphasic manner, indicating that TGF-beta1 induced TAK1 activation is tightly regulated ... The association of PP2A ( C ) with TAK1 is enhanced in response to TGF-beta1 stimulation and closely parallels TGF-beta1 induced TAK1 activity ... Endogenous TAK1 co-precipitates with PP2A ( C ) but not PP6 ( C ), another OA-sensitive protein phosphatase, and knockdown of PP6 ( C ) by small interfering RNA does not affect TGF-beta1 induced phosphorylation of TAK1 at Thr-187 and MKK3 ... Taken together, our data indicate that PP2A functions as a negative regulator in TGF-beta1 induced TAK1 activation
Neil et al., Cancer Res 2008 (Disease Progression) : Altered TAB1 : I kappaB kinase interaction promotes transforming growth factor beta mediated nuclear factor-kappaB activation during breast cancer progression
Sethi et al., Mol Cancer Ther 2008 (Neoplasm Invasiveness...) : Pinitol also suppressed the NF-kappaB reporter activity induced by tumor necrosis factor receptor (TNFR)-1, TNFR associated death domain, TNFR associated factor-2, transforming growth factor-beta activated kinase-1 ( TAK-1 ) /TAK1 binding protein-1 , and IkappaBalpha kinase but not that induced by p65
Kim et al., J Biol Chem 2009 : TAB1 does not interact with TGF-beta receptors, but TAB1 is indispensable for TGF-beta1 induced TAK1 activation