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ADAM19 — TGFB1

Text-mined interactions from Literome

Lim et al., J Cataract Refract Surg 2002 (Cataract) : To determine whether ADAM ( a disintegrin and metalloproteinase ) is regulated in lens epithelial cells ( LECs ) of patients with anterior polar cataracts and by transforming growth factor (TGF)-beta 1 in cultured LECs ... The effect of TGF-beta 1 on ADAM gene expression was also tested in mouse lens epithelial explants and cultured LEC lines ( alpha TN-4 and HLE B-3 )
Chan et al., Neoplasia (New York, N.Y.) 2008 (Ovarian Neoplasms...) : In this study, we show that TGF-beta1 causes growth inhibition of normal ovarian surface epithelial cells, induction of nuclear translocation SMAD4, and up-regulation of ADAM19 ( a disintegrin and metalloprotease domain 19 ), a newly identified TGF-beta1 target gene ... Although disrupted growth factor signaling has been linked to epigenetic gene silencing in cancer, this is the first evidence demonstrating that impaired TGF-beta1 signaling can result in the formation of a repressive chromatin state and epigenetic suppression of ADAM19