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HES1 — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Huang et al., Proc Natl Acad Sci U S A 2004
(Cell Transformation, Neoplastic) :
HES1 , HEY1, and TFAP4, which are members of the basic helix-loop-helix transcription family, and OSR1 were shown to
activate p53 through repression of HDM2 transcription
Kannan et al., J Exp Med 2013
(Leukemia, Myeloid, Acute) :
Induced activation through any of the Notch receptors ( Notch1-4 ), or through the Notch target
Hairy/Enhancer of Split 1 (HES1) , consistently leads to AML growth arrest and caspase dependent apoptosis, which are associated with B cell lymphoma 2 (BCL2) loss and
enhanced p53/p21 expression