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CCR2 — NFKB1
Text-mined interactions from Literome
Yang et al., J Immunol 2001
:
In addition to formyl peptide receptor, Galpha(16) also enhanced
NF-kappaB activation by the C5a and C3a receptors, and by CXC
chemokine receptor 2 and CCR8
Quinones et al., Mol Cell Neurosci 2008
(Demyelinating Diseases...) :
Using an in vitro system we demonstrate that expression of
CCR2 was functional in astrocytes and that signaling via this receptor
lead to activation of
NF-kB and Akt and was associated with increased astrocyte survival
Binder et al., Nat Med 2009
(Bone Resorption...) :
In normal mice, activation of
CCR2 in osteoclast progenitor cells
results in both
nuclear factor-kappaB (NF-kappaB) and extracellular signal related kinase 1 and 2 ( ERK1/2 ) signaling but not that of p38 mitogen activated protein kinase or c-Jun N-terminal kinase
Jimenez et al., J Immunol 2010
(Leishmaniasis, Cutaneous) :
We postulated that
CCR2-driven activation of the transcription factor
NF-kappaB plays a critical role in dendritic cell ( DC ) maturation ( e.g., migration, costimulation, and IL-12p70 production ), necessary for the generation of protective immune responses against the intracellular pathogen Leishmania major ... Collectively, our data point to an important role for
CCR2-driven activation of
NF-kappaB in the regulation of DC/LC maturation processes that regulate protective immunity against intracellular pathogens