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BCL6 — IL21
Text-mined interactions from Literome
Ozaki et al., J Immunol 2004
(Lupus Erythematosus, Systemic) :
Moreover, we demonstrate that
IL-21 unexpectedly
induces expression of both Blimp-1 and
Bcl-6 , indicating mechanisms as to how IL-21 can serve as a complex regulator of B cell maturation and terminal differentiation
Tsuruoka et al., Immunol Lett 2007
:
IL-21 has a pro-apoptotic effect on freshly isolated B cells stimulated with LPS, and also
induces Bcl6 expression in the activated B cells
Nurieva et al., Science 2009
:
Bcl6 expression is
regulated by interleukin-6 and
interleukin-21
Linterman et al., J Exp Med 2010
:
IL-21 acts directly on B cells to
regulate Bcl-6 expression and germinal center responses
Poholek et al., J Immunol 2010
:
Bcl6 upregulation and T ( FH ) cell differentiation were
independent of IL-6 and
IL-21 , revealing that either cytokine is not absolutely required for development of Bcl6 ( + ) T ( FH ) cells in vivo
Eto et al., PloS one 2011
:
The combined absence of IL-6 and
IL-21 resulted in reduced Tfh differentiation and
reduced Bcl6 protein expression
Nakayamada et al., Immunity 2011
:
Herein, we showed
interleukin-12 acting via the transcription factor STAT4
induced both Il21 and
Bcl6 genes, generating cells with features of both Tfh and Th1 cells