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SIRT1 — SLC22A3

Text-mined interactions from Literome

Byles et al., Oncogene 2012 (Neoplasm Metastasis...) : SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis ... Here, we propose a novel mechanism through which the nicotinamide adenine dinucleotide dependent histone deacetylase SIRT1 regulates EMT in prostate cancer cells through cooperation with the EMT inducing transcription factor ZEB1 ... We propose that the regulation of EMT by SIRT1 involves modulation of, and cooperation with, the EMT inducing transcription factor ZEB1 ... We thus identify a necessary role for ZEB1 in SIRT1 mediated EMT
Simic et al., Cell reports 2013 (Breast Neoplasms...) : Because sirtuins affect the pathology of aging, we tested the effect of SirT1 on EMT ... SIRT1 reduces EMT in cancer and fibrosis by deacetylating Smad4 and repressing the effect of TGF-ß signaling on MMP7, a Smad4 target gene