◀ Back to PTGS2

CYP19A1 — PTGS2

Text-mined interactions from Literome

Davies et al., Ann Oncol 2002 (Breast Neoplasms) : Cyclooxygenase-2 (COX-2), aromatase and breast cancer : a possible role for COX-2 inhibitors in breast cancer chemoprevention
Singh-Ranger et al., Curr Med Res Opin 2003 (Breast Neoplasms) : This observation is consistent with the hypothesis that COX-2 upregulates aromatase activity
Saji et al., Breast Cancer 2004 (Breast Neoplasms...) : As an endocrine application, overexpression of COX-2 contributes to increased expression of aromatase in the breast tumor
Brueggemeier et al., J Steroid Biochem Mol Biol 2005 (Breast Neoplasms) : The effects of NSAIDs ( ibuprofen, piroxicam, and indomethacin ), a COX-1 selective inhibitor ( SC-560 ), and COX-2 selective inhibitors ( celecoxib, niflumic acid, nimesulide, NS-398, and SC-58125 ) on aromatase activity and CYP19 expression were investigated in breast cancer cell culture systems
Su et al., J Med Chem 2006 (Breast Neoplasms...) : Structure-activity analysis does not find a correlation between aromatase suppression and COX-2 inhibition
Subbaramaiah et al., Cancer Res 2006 : In vitro, overexpressing COX-2 caused both increased PGE ( 2 ) production and aromatase activity, effects that were suppressed by celecoxib, a selective COX-2 inhibitor ... Consistent with this idea, COX-2 deficiency led to a gene dose dependent reduction in mammary aromatase activity in a HER-2/neu transgenic mouse model ... Complementary in vitro studies showed that HER-2/neu mediated induction of PGE ( 2 ) synthesis and aromatase activity were suppressed by inhibiting COX-2
Prosperi et al., Prostaglandins Other Lipid Mediat 2006 (Breast Neoplasms) : These studies demonstrate that Cox-2 directly regulates gene expression of specific aromatase promoter regions and regulates aromatase enzyme activity
Maia et al., Gynecol Endocrinol 2006 (Endometriosis...) : Increased aromatase activity may be responsible for the persistent COX-2 expression during the luteal phase
Salhab et al., J Surg Oncol 2007 (Adenocarcinoma...) : Increasing evidence supports a role for COX-2 in upregulation of aromatase activity
Haffty et al., Int J Radiat Oncol Biol Phys 2008 (Breast Neoplasms...) : The significance is limited to hormone receptor positive tumors, consistent with the known effect of COX-2/PGE2 on aromatase activity
Takeda et al., Toxicology 2009 (Breast Neoplasms) : However, the growth of MCF-7 cells induced by Delta ( 9 ) -THC was not stimulated by PGE ( 2 ), and the expression of aromatase was not affected by COX-2 inhibitors, arachidonic acid, and PGE ( 2 ), suggesting that there is a disconnection between COX-2 ( PGE ( 2 ) ) and aromatase in Delta ( 9 ) -THC mediated MCF-7 cell proliferation
Sirianni et al., J Biol Chem 2009 : In this study, we investigated the role of cyclooxygenase-2 (COX-2) in CREB dependent-aromatase expression in Leydig tumor cells
Han et al., Toxicol Lett 2010 (Breast Neoplasms) : The role of cyclooxygenase-2 dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o, p'-DDT in human breast cancer cells ... We also examined whether cyclooxygenase-2 (COX-2) is involved in o, p'-DDT mediated aromatase expression
Martin et al., Breast Cancer Res Treat 2010 (Breast Neoplasms) : Cyclo-oxygenase 2 (COX-2) is implicated in the regulation of aromatase transcription in malignant breast tissue and has been considered as a potential target for tissue specific aromatase suppression
Subbaramaiah et al., Cancer Discov 2012 : Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women
Olivares et al., Reproduction 2013 (Endometriosis...) : In this study, the effect of combining celecoxib, a selective COX-2 inhibitor, and anastrozole, an aromatase inhibitor , on the implantation and growth of endometriotic like lesions in a murine model of endometriosis was evaluated