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NFKBIA — NOS2

Text-mined interactions from Literome

Taylor et al., Surgery 1999 : Western blot analysis showed a marked decrease in iNOS protein levels in the presence of Ad5I kappa B alpha
Wang et al., Br J Pharmacol 1999 (Brain Neoplasms...) : Nepalolide A inhibits the expression of inducible nitric oxide synthase by modulating the degradation of IkappaB-alpha and IkappaB-beta in C6 glioma cells and rat primary astrocytes
Nomura et al., Nihon Yakurigaku Zasshi 1999 (Glioma...) : To elucidate the intracellular mechanism of NF-kappa B activation, we performed the involvement of I kappa B alpha of NF-kappa B in the expression of inducible NO synthase (iNOS) and chemokine ( CINC ) following pretreatment with bacterial endotoxin ( LPS ) or IL-1 beta, respectively, using rat C6 glioma cells
Eaves-Pyles et al., J Immunol 2001 (Salmonella Infections, Animal...) : Flagellin, a novel mediator of Salmonella induced epithelial activation and systemic inflammation : I kappa B alpha degradation, induction of nitric oxide synthase , induction of proinflammatory mediators, and cardiovascular dysfunction
Nomura et al., Life Sci 2001 : Experiments using stable clones of rat C6 glioma cells transfected with dominant negative IkappaB alpha ( serines 32 and 36 replaced by alanine ) suggest that NF-kappaB activation ( phosphorylation of IkappaB alpha ) is involved in LPS/IFNgamma- or IL-1beta/IFNgamma induced iNOS expression
Kang et al., J Biol Chem 2003 : Protein kinase C depletion inhibited I-kappaBalpha degradation, NF-kappaB activation, and iNOS induction by thrombin or the iNOS induction by Galpha(12/13)QL
Chen et al., Carcinogenesis 2005 : Furthermore, impairing nuclear factor-kappaB (NFkappaB) activation by either NEMO-BDBP, an NFkappaB specific inhibitor, or overexpression of DN-IkappaBalpha or IKK-KM markedly inhibited the expression of B [ a ] P-induced iNOS , suggesting that the NFkappaB pathway is also required for the induction of iNOS by B [ a ] P
Choi et al., Eur J Pharmacol 2007 : These results suggest that isoeugenol and its analogues inhibit NO production and iNOS expression in LPS stimulated RAW 264.7 cells, and that these effects are mediated , at least in part, by blocking the phosphorylation of ERK1/2 and p38 kinase, degradation of I-kappaBalpha , and activation of NF-kappaB
Kizaki et al., Immunology 2008 : These findings suggest that LPS stimulated signals suppress beta ( 2 ) AR expression, leading to down-regulation of beta-arrestin 2 expression, which stabilizes cytosolic IkappaBalpha and inhibits the NF-kappaB activation essential for NOS II expression, probably to ensure rapid and sufficient production of NO in response to microbial attack