Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
PRKCZ
→
TNF
(increases, TNF Activity)
Evidence: treated BAECs with TNFalpha (0-10 ng/mL; 15 minutes), and PKCzeta activity was measured by phosphorylation at Thr410 (p-PKCzeta) by immunoblotting (Figure 1A-B). There was a significant 3-fold increase in PKCzeta activity
OpenBEL Selventa BEL large corpus:
PRKCZ
→
TNF
(increases, TNF Activity)
Evidence: Jung et al. [36] recently investigated TNF-a-induced HIF-1a accumulation and demonstrated that an NFkB-mediated event that is normally associated with inflammation and cell survival caused protein accumulation in normoxic cells. Although the report fails to identify the mechanism of HIF-1a accumulation, it is suggested that this might interfere with the pVHL-mediated HIF-1a degradation process. Further studies support the concept of a pVHL-dependent cytotoxicity to TNF-a in RCC cells [37,38]. In...