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ITGA5 — PXN

Pathways - manually collected, often from reviews:

• KEGG Focal adhesion: PXN → Complex of 21 proteins (protein-protein, binding/association)
• NCI Pathway Database CXCR4-mediated signaling events: alpha-beta1 Integrin (ITGA8/ITGB1/ITGA10/ITGB1/ITGA6/ITGB1/ITGA1/ITGB1/ITGA3/ITGB1/ITGA2/ITGB1/ITGAV/ITGB1/ITGA11/ITGB1/ITGA4/ITGB1/ITGA7/ITGB1/ITGA5/ITGB1/ITGA9/ITGB1) → FAK/p130 Cas/Paxillin complex (PTK2-BCAR1-PXN) (cell adhesion, collaborate)
  Okabe et al., J Hematother Stem Cell Res 2002, Glodek et al., Leukemia 2007
  Evidence: mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of PXN-ITGB1-ITGA5-FN1 (association, cross-linking study) Humphries et al., Science signaling 2009

Text-mined interactions from Literome

Lu et al., Mol Pharmacol 2006 : Compared with docetaxel, laulimalide more potently caused a reduction in the constitutive levels ( i.e., in the absence of VEGF ) of phosphorylated paxillin and more potently inhibited the association of RhoA with the alpha5beta1 integrin
Liu et al., Exp Eye Res 2006 : These results suggest that fibronectin promoted CF-mediated collagen gel contraction in a manner dependent on the formation of stress fibers and focal adhesions, the activation of paxillin , and the up-regulation of integrin alpha5beta1