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MCL1 — RELA

Text-mined interactions from Literome

Hall et al., Cancer Cell 2007 (Neoplasms) : In this issue of Cancer Cell, El-Deiry and colleagues explore pathways that disrupt TRAIL induced survival signaling and show that the Myc oncoprotein and the Raf kinase inhibitor Sorafenib sensitize otherwise TRAIL-resistant colon cancer cells by effectively reducing NF-kappaB mediated transcription of Mcl-1
Ricci et al., Cancer Cell 2007 : TRAIL induced expression of antiapoptotic Mcl-1 and cIAP2 through activation of NF-kappaB
D'Angelo et al., J Cell Physiol 2008 : The failure of the mycERtrade mark transgene to cause the apoptotic response is associated with reduced levels of RIP1 expression, increased Mcl-1 expression and activation of both NF-kB and Akt
El Kihel et al., Bioorg Med Chem 2008 (Colonic Neoplasms...) : This activity was associated with Mcl-1 and PARP-1 cleavage, inhibition of NFkappaB signaling, and DNA fragmentation, demonstrating an apoptotic cell death signaling pathway
Ammann et al., Int J Cancer 2009 (Neuroblastoma) : Analysis of signaling pathways reveals that NF-kappaB inhibition prevents TRAIL triggered up-regulation of Mcl-1 , promoting TRAIL induced cytochrome c release and activation of caspases
Park et al., Toxicol In Vitro 2010 (Carcinoma, Squamous Cell...) : These findings collectively suggest that aspirin induces apoptosis in YD-8 cells and the induction may be correlated to activation of caspases, caspase dependent Mcl-1 proteolysis, inactivation of ERK-1/2 and AKT, and activation of NF-kappaB