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BMP2 — VEGFA
Text-mined interactions from Literome
Nagineni et al., J Cell Physiol 2003
(MAP Kinase Signaling System...) :
In contrast activin, inhibin and
BMP , members of TGF-beta super family,
had no effects on
VEGF expression in HRPE
Dai et al., Cancer Res 2004
(Bone Neoplasms...) :
Furthermore,
BMP-7 activated the
VEGF promoter
Kohno et al., J Orthop Sci 2007
:
These results indicate that FGF-2 and
VEGF contribute to fibrous integration between the tendon and bone during the early postoperative stage, and that
BMP-2 and BMP-7 are specifically
involved in bone remodeling leading to osseous integration
Chu et al., Chin J Traumatol 2007
(Radius Fractures) :
On the contrary,
anti-VEGF completely
inhibited the expression of
BMP
Kärner et al., Biochim Biophys Acta 2009
:
BMP2 induced the expression of principle osteogenic factors, such as osterix, bone sialoprotein and osteocalcin, whereas
VEGF had the converse effect on the gene expression pattern
Yao et al., J Clin Invest 2011
(Arteriovenous Malformations...) :
In cultured lung epithelial cells,
BMP-4 induced
VEGF expression through induction of ALK1, ALK2, and ALK5
Yang et al., J Dent Res 2012
:
This vascular niche and numbers of CD146+ pericytes are likely controlled by odontogenic and
Bmp2 dependent
VegfA production in odontoblasts
Chen et al., Biochem Biophys Res Commun 2012
:
Moreover,
BMP-2 stimulation
led to upregulation of Osx and
VEGF , but not HIF-1a
Bai et al., Development 2013
(Truncus Arteriosus, Persistent...) :
To determine if Vegfa is a downstream Bmp effector during EMT, we examined whether
Vegfa is transcriptionally
regulated by the
Bmp receptor regulated Smad