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BMP2 — RUNX1
Text-mined interactions from Literome
Phimphilai et al., J Bone Miner Res 2006
:
Conversely,
RUNX2 expression synergistically
stimulated BMP2 signaling in C3H10T1/2 cells
Komaki et al., J Cell Biochem 2007
:
In contrast,
BMP-2 increased
runt related transcription factor ( Runx)-2, but failed to enhance alkaline phosphatase (ALP) and osteocalcin ( OCN ) gene expression in PDL cells
Naganawa et al., J Cell Biochem 2008
(MAP Kinase Signaling System) :
Interestingly,
BMP-2 induced nuclear accumulation of the
runt related transcription factor ( Runx2 ) was markedly impaired in osteoblasts from Fgf2-/- mice ... Interestingly,
BMP-2 induced nuclear accumulation of the
runt related transcription factor ( Runx2 ) was markedly impaired in osteoblasts from Fgf2-/- mice
Chiou et al., Life Sci 2011
:
Induction of differentiation by 8-PK was associated with increased
bone morphogenetic protein (BMP)-2 expression, and sequentially up-regulated the phosphorylations of Smad1/5/8 and p38, and
increased the nuclear translocation of
runt related transcription factor 2 ( Runx2 )
Yoshioka et al., Eur J Immunol 2012
:
Notably,
BMP signalling
controlled the phosphorylation of
RUNX1 , revealing the molecular nature of its effect