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AKT2 — BMP2
Text-mined interactions from Literome
Sugimori et al., J Bone Miner Metab 2005
:
We investigated the involvement of phosphatidylinositol 3-kinase
(PI3K)/Akt mediated NF-kappaB activation by
BMP-2 stimulation in the modulation of this antiapoptotic process in a chondrocytic cell line, N1511
Itoh et al., J Gastroenterol 2006
:
Furthermore,
BMP2 inhibited MSE1 cell proliferation in MTS assays and
suppressed AKT phosphorylation
Segrelles et al., Mol Biol Cell 2008
(Nails, Malformed...) :
Constitutively active
Akt induces ectodermal defects and impaired
bone morphogenetic protein signaling
Wu et al., Eur J Pharmacol 2008
:
The transcriptional regulation of
BMP-2 by naringin was
mediated by phosphorylation of
Akt and activation of the activator protein-1 (AP-1) components c-Fos and c-Jun
Fong et al., J Cell Physiol 2008
(Chondrosarcoma) :
BMP-2 increased the phosphorylation of p85 subunit of PI3K and serine 473 of
Akt ... Taken together, these results suggest that the
BMP-2 acts through
PI3K/Akt , which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of beta1 integrin and contributing the migration of human chondrosarcoma cells
Graham et al., Prostate 2009
(Neoplasm Metastasis...) :
PI3K/Akt dependent transcriptional regulation and activation of
BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells ... Selective inhibition of
PI3K/Akt suppressed the NF-kappaB induced
BMP-2 promoter activity
Lee et al., Stem Cells 2009
:
In addition,
BMP-4 induced
Akt phosphorylation
Johnsen et al., Cancer Res 2009
(Adrenal Cortex Neoplasms...) :
This growth inhibitory effect was associated with
BMP dependent reduction of
AKT phosphorylation under baseline conditions and under insulin-like growth factor costimulation
Mandal et al., Endocrinology 2009
:
Inhibition of
PI3K/Akt signaling
blocked the binding of Smads 1/5 to the CSF-1
BMP-responsive element present in the CSF-1 promoter, resulting in attenuation of Smad dependent CSF-1 transcription
Perez et al., J Cell Biol 2011
(Neointima) :
We show that
BMP-2 , in a
phospho-Akt dependent manner, induces ßC transcriptional activity to produce fibronectin, which then activates integrin linked kinase 1 (ILK-1) via a4-integrins
Choi et al., Biochem Biophys Res Commun 2011
:
These results suggest that
Akt activity enhances the osteogenic function of Osterix, at least in part, through protein stabilization and that
BMP-2 regulates the osteogenic function of Osterix, at least in part, through Akt
Liu et al., Biochem Biophys Res Commun 2013
:
Furthermore, in the presence of exogenous
BMP-2 , PI3K and
Akt inhibitors
blocked Runx2 and osteocalcin expression, although BMP-2 did not activate Akt
Ueki et al., Glia 2013
:
Interestingly,
BMP/Smad1/5/8 activation downstream of
PI3K/AKT signaling was also necessary for robust Müller glial proliferation, though activation of BMP/Smad1/5/8 signaling alone failed to stimulate their proliferation
Ghosh-Choudhury et al., J Biol Chem 2013
:
Remarkably, inhibition of c-Abl significantly suppressed
BMP-2 stimulated PI 3-kinase activity and its downstream
Akt phosphorylation