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CEBPB — EGR1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: EGR1 → Complex of CEBPB-EGR1 (directlyIncreases, CEBPB/EGR1 Activity) Zhang et al., J Biol Chem 2003*
  Evidence: treating HepG2 cells with OM specifically leads to prominent increases of the levels of c/EBPbeta and Egr1 bound to the LDLR promoter in vivo the N-terminal transactivation domain of Egr1 specifically interacts with c/EBPbeta The OM treatment further enhances this interaction, resulting in a large increase in the Egr1 transactivating activity Egr1 regulates LDLR transcription via a novel mechanism of protein-protein interaction with c/EBPbeta.
• OpenBEL Selventa BEL large corpus: Complex of CEBPB-EGR1 → OSM (increases) Zhang et al., J Biol Chem 2003*
  Evidence: treating HepG2 cells with OM specifically leads to prominent increases of the levels of c/EBPbeta and Egr1 bound to the LDLR promoter in vivo the N-terminal transactivation domain of Egr1 specifically interacts with c/EBPbeta The OM treatment further enhances this interaction, resulting in a large increase in the Egr1 transactivating activity Egr1 regulates LDLR transcription via a novel mechanism of protein-protein interaction with c/EBPbeta.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: EGR1 — CEBPB Zhang et al., J Biol Chem 2003*
• IRef Bind_translation Interaction: EGR1 — CEBPB (two hybrid) Zhang et al., J Biol Chem 2003*
• IRef Bind_translation Interaction: EGR1 — CEBPB (coimmunoprecipitation) Zhang et al., J Biol Chem 2003*
• IRef Biogrid Interaction: EGR1 — CEBPB (direct interaction, two hybrid) Zhang et al., J Biol Chem 2003*
• IRef Biogrid Interaction: EGR1 — CEBPB (direct interaction, pull down) Zhang et al., J Biol Chem 2003*
• IRef Hprd Interaction: EGR1 — CEBPB (in vivo) Zhang et al., J Biol Chem 2003*
• IRef Ophid Interaction: EGR1 — CEBPB (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: EGR1 — CEBPB (aggregation, confirmational text mining) Zhang et al., J Biol Chem 2003*