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EPHB2 — HLA-DRB1
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Shenoy et al., Cancer Res 2009
(Neuroblastoma) :
Finally, small interfering RNA mediated gene silencing of JNK and
ERK inhibited LY30 induced increase in surface expression of
DR4 and DR5, respectively
Park et al., Toxicol In Vitro 2010
:
Combined treatment with esculetin and HA14-1 upregulated the expression of
death receptor 4 (DR4) , and
activation of
extracellular regulated kinase (ERK) in a time dependent manner ... In addition, esculetin and HA14-1 mediated apoptosis was reduced by ERK inhibitors through inhibition of DR4 expression, suggesting that the synergistic effect was at least partially mediated through
ERK dependent induction of
DR4 expression ... The results indicate that HA14-1 induced reversal of the anti-apoptotic effect of Bcl-2 confers apoptosis sensitivity to esculetin by a mitochondrial amplification step and through the
ERK dependent induction of
DR4 expression in U937/Bcl-2 cells
Oh et al., J Biol Chem 2010
:
Thus,
ERK/RSK dependent, CHOP and Elk1 mediated mechanisms are
critical for
DR5 induction
Gupta et al., J Biol Chem 2011
(Adenocarcinoma...) :
Overall, our results indicate that nimbolide can sensitize colon cancer cells to TRAIL induced apoptosis through three distinct mechanisms : reactive oxygen species- and
ERK mediated up-regulation of DR5 and
DR4 , down-regulation of cell survival proteins, and up-regulation of p53 and Bax
Stolfi et al., Mol Cancer Ther 2011
(Colonic Neoplasms) :
2-14 promoted
ERK dependent
induction of
DR5 , thereby enhancing TRAIL mediated caspase-8 activation and apoptosis
Yan et al., J Cancer Res Clin Oncol 2012
(Breast Neoplasms...) :
Inhibition of the activation of
ERK , JNK and p38 MAPK by specific inhibitors
attenuated DR4 and
DR5 up-regulation
Xu et al., Mol Cancer Ther 2012
(Lung Neoplasms) :
In addition, we discovered that the phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2 and RSK2 were elevated after PS-341 treatment and inhibition of their phosphorylation using MAP-ERK kinase 1/2 inhibitor decreased the DR5 level, indicating that
ERK/RSK2 signaling is
involved in
DR5 upregulation
Kim et al., Mol Cells 2013
:
Sub-toxic dose of apigenin sensitizes HepG2 cells to TRAIL through
ERK dependent up-regulation of TRAIL receptor
DR5 ... Next, using pharmacological inhibitors, we found that
ERK activation is
involved in the induction of
DR5 expression ... Taken together, our results indicate that apigenin can enhance the apoptotic effect of TRAIL via
ERK induced up-regulation of
DR5