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EPHB2 — GAB2
Text-mined interactions from Literome
Dorsey et al., Blood 2002
(Leukemia, Myeloid) :
Analysis of these cell lines indicated that induction of
Gab2WT expression, but not Gab2Tyr604Phe expression,
led to
Erk activation, growth arrest, cell spreading, and enlargement ; expression of megakaryocyte/platelet lineage-specific integrins alphaIIb/beta3 ( CD41/CD61 ) ; and upregulation of RNA for megakaryocyte/platelet proteins
Yu et al., Blood 2002
:
Biochemical analyses revealed that enforced expression of
Gab2 mutant molecules dramatically
reduced beta ( 1 ) -integrin ligation triggered PI3 kinase activation, whereas
Erk kinase activation remained unaltered
Koncz et al., Immunol Lett 2002
:
Since
ERK is
regulated by the phosphorylated
Gab1/2 , these data demonstrate that BCR triggered phosphorylation and signal amplification of Gab1/2 is a critical step in a life or death decision of B cells
Arnaud et al., Biochem J 2004
(Leukemia, Prolymphocytic, T-Cell) :
Expression of the Gab2 Tyr-614 -- > Phe ( Y614F ) mutant, defective in SHP-2 association, prevents ERK ( extracellular-signal regulated kinase ) activation and expression of a luciferase reporter plasmid driven by the c-fos SRE ( serum response element ), indicating that interaction of SHP-2 with
Gab2 is
required for
ERK activation in response to IL-2
Arnaud et al., J Immunol 2004
(MAP Kinase Signaling System) :
This migration shift was strongly diminished by treating cells with the MEK inhibitor U0126, indicating a possible
role for
ERK in
Gab2 phosphorylation ... We report that pretreatment of Kit 225 cells with U0126 increased Gab2/SHP-2 association and tyrosine phosphorylation of SHP-2 in response to IL-2, suggesting that
ERK phosphorylation of serine 623
regulates the interaction between
Gab2 and SHP-2, and consequently the activity of SHP-2
Mao et al., J Cell Biol 2005
:
Gab2 suppression
reduces bFGF dependent activation of AKT but not
ERK , and constitutively active AKT, but not constitutively active MEK1, reverses the hypersensitization
Simoncic et al., Mol Cell Biol 2006
:
Tcptp-/- macrophages also have increased tyrosine phosphorylation and recruitment of a
Grb2/Gab2/Shp2 complex to the CSF-1R and enhanced
activation of
Erk after CSF-1 stimulation, which are important molecular events in CSF-1 induced differentiation