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IL6 — TAT

Text-mined interactions from Literome

Kutsch et al., J Virol 2000 (HIV Infections) : Herein, we demonstrate that HIV-1 Tat ( 72aa ) is a potent inducer of MCP-1, interleukin-8 (IL-8), and IP-10 expression in astrocytes
Marinaro et al., Vaccine 2003 : Furthermore, their splenocytes proliferated and secreted IFN-gamma and IL-6 in response to Tat
Zvibel et al., J Cell Physiol 2004 : On the other hand, IL-6c strongly reduced , in a dose-dependant manner, expression of albumin and tyrosine aminotransferase (TAT)
Hui et al., Yao Xue Xue Bao 2006 : The effects of SPMG on Tat induced TNFalpha ( 4 h ), IL-1beta and IL-6 ( 6 h ) secretion in THP-1 cells were measured by ELISA
Zeng et al., J Virol 2007 (HIV Infections...) : Mechanistic studies showed ectopic expression of Tat induced the production of human interleukin-6 ( huIL-6 ) and its receptor ( huIL-6Ra ) and activated STAT3 signaling
Turchan-Cholewo et al., Antioxid Redox Signal 2009 : Furthermore, inhibition of NADPH oxidase attenuated Tat induced release of interleukin-6 (IL-6) , tumor necrosis factor alpha (TNF), and monocyte chemoattractant protein 1 ( MCP-1 ), and decreased microglial mediated neurotoxicity
El-Hage et al., PloS one 2008 : Pretreatment with the NF-kappaB inhibitor parthenolide provided evidence that Tat+/-morphine induced release of MCP-1, IL-6 and TNF-alpha by astrocytes is NF-kappaB dependent
Fu et al., Journal of neuroinflammation 2011 (HIV Infections...) : SB 202190 significantly decreased IDO expression induced by Tat, and this effect was accompanied by a reduction of Tat induced expression of TNFa, IL-6 , iNOS and SERT
Yu et al., Peptides 2012 (Body Weight...) : PACAP-TAT decreased myeloperoxidase (MPO) activity, increased catalase (CAT) activity and down-regulated interleukin 6 (IL-6) and malondialdehyde ( MDA ) levels in the lungs with a significantly higher efficiency than PACAP
Rautonen et al., AIDS Res Hum Retroviruses 1994 (HIV Infections) : We conclude that Tat can function in vitro in the absence of any other viral structures and induce Ig and IL-6 production ; the clinical significance of these findings remains as yet undetermined
Scala et al., J Exp Med 1994 (Cell Transformation, Neoplastic) : By cotransfecting the pIL6Pr-CAT and the tat expressing pSVT8 plasmid in MC3 B-lymphoblastoid or in HeLa epithelial cells, we observed that TAT transactivates the human IL-6 promoter ... 5 ' deletion plasmids of pIL6Pr-CAT, in which regions at -658, -287, and -172 were inserted 5 ' to the cat gene, were transiently transfected in pSVT10 and pSVT8 cells and showed that TAT induced activation of the IL-6 promoter required a minimal region located between -287 and -54 bp ... The biological relevance of the TAT induced IL-6 secretion was addressed by generating 7TD1 cells, an IL-6 dependent mouse cell line, stably expressing the tat gene
Poggi et al., J Biol Chem 1998 : Here we demonstrate that Tat inhibits apoptotic body engulfment and interleukin-12 production by blocking extracellular calcium influx
Zidovetzki et al., AIDS Res Hum Retroviruses 1998 : Both the Tat induced increase in intracellular cAMP and IL-6 mRNA levels in CNS-ECs may play a role in altering the blood-brain barrier and thereby inducing pathology often observed in AIDS dementia
Ito et al., AIDS Res Hum Retroviruses 1998 : Tat at the same concentrations did not affect IL-10, IL-6 , or TNF-alpha production
Matsutani et al., J Surg Res 1998 (Carcinoma...) : Methylprednisolone treatment effectively inhibited the increases in TNF-alpha and IL-6 and the decreases in AT-III and albumin, but did not inhibit the increases in PMN-elastase and TAT levels