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IRF6 — VCAM1

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Simoncini et al., J Clin Endocrinol Metab 1999 : We studied the relative effects of the raloxifene analogue LY117018 and of tamoxifen on lipopolysaccharide (LPS) induced VCAM-1 expression in cultured human saphenous vein endothelial cells ( HSVEC ) and on HSVEC adhesiveness towards U937 monocytoid cells
Morise et al., Inflammation 1999 : Constitutive and LPS stimulated expression of intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and E-selectin were measured in wild type C57BL/6 and IL-10 deficient mice with no signs of active enterocolitis, using the dual radiolabeled monoclonal antibody technique ... However, we demonstrated larger increments in LPS induced expression of ICAM-1 and VCAM-1 in the vasculature of the small intestine in IL-10 deficient mice compared to WT mice ... These findings suggest that endogenous IL-10 does not modulate constitutive or LPS induced expression of ECAMs in most tissues, however it does appear to play an inhibitory role in LPS stimulated expression of ICAM-1 and VCAM-1 in the intestinal vasculature
McGilvray et al., Can J Surg 1999 (Dermatitis...) : Both ICAM-1 and VCAM-1 were upregulated in response to LPS ; however, only the increase in VCAM-1 was attenuated by antioxidant pretreatment
Yamashita et al., Circulation 2000 (Edema...) : LPS induced increases in the expression of the mRNA of both vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 in the lungs were significantly lower in Tg mice than in control mice
Kalden et al., Ann N Y Acad Sci 1999 (Inflammation) : Thus, we investigated the influence of alpha-MSH on the LPS induced expression of the adhesion molecules E-selectin and VCAM-1 on endothelial cells ... RT-PCR analysis showed that alpha-MSH significantly reduced LPS induced expression of VCAM-1 and E-selectin
Simoncini et al., Mol Cell Endocrinol 2000 (Arteriosclerosis) : Tibolone and its two estrogenic 3alpha-OH and 3beta-OH metabolites, but not the progestogenic/androgenic Delta(4)-isomer, concentration-dependently decreased LPS induced vascular cell adhesion molecule-1 protein expression
Simoncini et al., Circ Res 2000 : To determine the mechanism by which estrogen regulates VCAM-1 expression, we compared the effect of 17beta-estradiol ( E ( 2 ) ) and of the glucocorticoid dexamethasone ( Dex ) on lipopolysaccharide (LPS) induced VCAM-1 expression in human endothelial cells ... Transfection of endothelial cells with a functional VCAM-1 promoter construct showed that E ( 2 ) inhibited LPS induced VCAM-1 gene transcription more potently than did Dex
Tummala et al., J Mol Cell Cardiol 2000 : DPI also inhibited TNF and LPS induced VCAM-1 and ICAM-1 cell surface expression and TNF- alpha, LPS , or IL-1 beta induced VCAM-1 and ICAM-1 mRNA accumulation
Raeburn et al., Surgery 2001 (Sepsis) : LPS caused a time dependent increase in both myocardial VCAM-1 expression and neutrophil accumulation
Scholzen et al., Endocrinology 2003 (Vasculitis) : In HDMEC, alpha-MSH ( 10 ( -8 ) /10 ( -12 ) M ) profoundly reduced the mRNA and protein expression of E-selectin, vascular CAM (VCAM)-1 , and intercellular CAM (ICAM)-1 induced by LPS or TNFalpha as determined by semiquantitative RT-PCR, ELISA, and fluorescence activated cell sorter analysis
Zhang et al., Thromb Haemost 2003 : Furthermore, by using specific cell ELISAs we could show that AS-IV decreased the LPS induced expression of E-selectin and VCAM-1 on the surface of HUVECs in a dose and time dependent manner, whereas the expression of ICAM-1 was not affected by AS-IV ... The saponin octyl-D-glucopyranoside had no effect on the LPS induced expression of E-selectin and VCAM-1 excluding an unspecific detergent-like effect of AS-IV
Croner et al., Microvasc Res 2004 (Sepsis) : VCAM-1 m-RNA expression in the hepatic tissue was markedly and C3a levels in plasma were significantly reduced in the LPS + C1-INH vs. the LPS + SC group
Witzenbichler et al., Circulation 2005 (Pulmonary Edema...) : Furthermore, LPS induced increases in the expression level of vascular cell adhesion molecule-1 , intracellular adhesion molecule-1, and E-selectin protein in the lungs were markedly lower in AdhAng1 mice than in control mice
Jeyaseelan et al., J Immunol 2005 (Escherichia coli Infections...) : LPS induced neutrophil sequestration ; NF-kappaB translocation ; keratinocyte cell derived chemokine, MIP-2, TNF-alpha, and IL-6 expression ; histopathology ; and VCAM-1 and ICAM-1 expression were abolished in the lungs of TIRAP-/- mice
Takahashi et al., J Antibiot (Tokyo) 2006 : We confirmed that surfactin inhibited LPS induced expression of ICAM-1 and VCAM-1 in HUVEC
Tong et al., FEBS Lett 2006 (Acute Disease...) : This HIMF production, at least partly, contributes to LPS induced vascular cell adhesion molecule-1 ( VCAM-1 ) upregulation and mononuclear cell sequestration to lung parenchyma, while protecting alveolar type II cells from LPS resulted decrease in surfactant protein-C production and cell death
Tong et al., Am J Respir Cell Mol Biol 2006 : Knockdown of HIMF expression by small interference RNA attenuated LPS induced VCAM-1 expression in vitro
Lin et al., Cell Signal 2007 : Involvement of MAPKs and NF-kappaB in LPS induced VCAM-1 expression in human tracheal smooth muscle cells ... Here, the roles of mitogen activated protein kinases ( MAPKs ) and nuclear factor-kappaB (NF-kappaB) pathways for LPS induced vascular cell adhesion molecule (VCAM)-1 expression were investigated in HTSMCs. LPS induced expression of VCAM-1 protein and mRNA in a time dependent manner, was significantly inhibited by inhibitors of MEK1/2 ( U0126 ), p38 ( SB202190 ), and c-Jun-N-terminal kinase ( JNK ; SP600125 ) ... The involvement of p42/p44 MAPK and p38 in these responses was further confirmed by that transfection with small interference RNAs ( siRNA ) direct against MEK, p42, and p38 significantly attenuated LPS induced VCAM-1 expression ... In addition, LPS induced VCAM-1 expression was significantly blocked by a specific NF-kappaB inhibitor helenalin ... Taken together, these results suggest that in HTSMCs, activation of p42/p44 MAPK, p38, and JNK pathways, at least in part, mediated through NF-kappaB, is essential for LPS induced VCAM-1 gene expression
Singh et al., Phytomedicine 2008 : The major CAMs, viz., intercellular adhesion molecule-1 ( ICAM-1 ), VCAM-1 and E-selectin are expressed on endothelium in response to various cytokines or bacterial LPS
Sawa et al., J Histochem Cytochem 2008 : The LPS induced IL-6, IL-8, VCAM-1 , and ICAM-1 production in LEC was suppressed by the introduction of TLR4-specific small interfering RNA, and also by anti-TLR4, nobiletin, and CAPE pretreatment
Huang et al., Journal of inflammation (London, England) 2007 : Hepatic VCAM-1 and iNOS protein and mRNA were induced by LPS more in mice fed HCD than CD
Cheng et al., Mol Immunol 2008 : LPS induced upregulation of vascular cell adhesion molecule-1 ( VCAM-1 ) could be suppressed by treatment with iC1INH
Lin et al., Toxicol Appl Pharmacol 2008 : Here, we reported that LPS induced up-regulation of VCAM-1 enhanced the adhesion of neutrophils onto HTSMC monolayer, which was inhibited by LY294002 and wortmannin ... LPS stimulated Src, PYK2, EGFR, and Akt phosphorylation and VCAM-1 expression were attenuated by the inhibitors of Src ( PP1 ), EGFR ( AG1478 ), PI3-K ( LY294002 and wortmannin ), and Akt ( SH-5 ), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110 ... LPS induced VCAM-1 expression was also blocked by pretreatment with curcumin ( a p300 inhibitor ) or transfection with p300 siRNA ... LPS induced p300 activation enhanced VCAM-1 promoter activity and VCAM-1 mRNA expression ... These results suggested that in HTSMCs, Akt phosphorylation mediated through transactivation of Src/PYK2/EGFR promoted the transcriptional p300 activity and eventually led to VCAM-1 expression induced by LPS
Lee et al., J Endod 2008 (Pulpitis) : The purpose of this study was to determine the effects of terrein on lipopolysaccharide (LPS) induced expression of intercellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) in human dental pulp cells and to determine the mechanism of the observed effects ... The LPS induced expression of ICAM-1 and VCAM-1 was inhibited by terrein in both a time- and dose dependent manner
Mikkelsen et al., Histochem Cell Biol 2008 (Inflammation...) : LPS induced VCAM-1 activation of the vessels, modest influx of granulocytes, as well as an iNOS-activation in a cell type different from macrophages in both +/+ and op/op mice
Kadl et al., Arthritis Rheum 2009 (Inflammation...) : LPS , but not OxPAPC, induced the expression of adhesion molecules E-selectin, P-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1
Binion et al., Am J Physiol Gastrointest Liver Physiol 2009 : Tumor necrosis factor (TNF)-alpha/lipopolysaccharide (LPS) induced VCAM-1 expression in HIMEC was suppressed by Akt small interfering RNA, curcumin, and inhibitors of NF-kappaB ( SN-50 ), p38 MAPK ( SB-203580 ) and PI 3-kinase/Akt ( LY-294002 )
Datta et al., Atherosclerosis 2010 (Inflammation) : Moreover, Ac-hE18A-NH ( 2 ) inhibited LPS induced vascular cell adhesion molecule-1 ( VCAM-1 ) expression, and reduced monocyte adhesion in human umbilical vein endothelial cells ( HUVECs )
Kim et al., Kidney Int 2009 (Acute Kidney Injury) : Treatment also mitigated the effects of LPS on renal intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 protein expression, the number of ER-HR3 positive macrophages that infiltrated the kidney, serum nitrate/nitrite levels, renal inducible nitric oxide synthase protein expression, the induction of tubular epithelial reactive oxygen and nitrogen species, and renal microvascular permeability
Wang et al., Cytokine 2010 : Furthermore, ApoA-I significantly inhibited LPS induced CD11b and VCAM-1 expression on THP-1 cells ( P < 0.01, P < 0.05, respectively )
Wu et al., J Cell Physiol 2010 (Arthritis, Rheumatoid) : In this study, we identified that cPLA(2)alpha acted as a modulator of LPS induced VCAM-1 expression and THP-1 ( human acute monocytic leukemia cell line ) adherence ... Moreover, COX-2 derived PGE ( 2 ) production appeared to involve in LPS induced VCAM-1 expression which was attenuated by pretreatment with selective COX-2 inhibitors ( NS-398 and celecoxib ), transfection with COX-2 siRNA, or PGE ( 2 ) receptor antagonists ... Collectively, these results suggest that LPS induced VCAM-1 expression and adhesion of THP-1 cells are mediated through the TLR4/ERK/cPLA(2)alpha phosphorylation and COX-2 expression/PGE ( 2 ) synthesis in RASFs
Lubos et al., FASEB J 2010 : GPx-1 deficiency also transiently augmented LPS induced vascular cell adhesion molecule-1 ( VCAM-1 ) expression
Andreasen et al., Intensive Care Med 2010 (Diabetes Mellitus, Type 2...) : Type 2 diabetes was associated with less pronounced LPS induced increases in TNF, IL-1ra, VCAM-1 and ICAM-1
Lapointe et al., J Cell Physiol 2010 (Disease Models, Animal...) : Together, our data demonstrate the role of sPLA ( 2 ) -V in LPS induced ICAM-1 and VCAM-1 protein overexpression and leukocyte recruitment, supporting the contribution of sPLA ( 2 ) -V in the development of inflammatory innate immune responses
Gorina et al., Glia 2011 : LPS induced early activation of the transcription factor NF?B, through the MyD88 adaptor, and expression of TNF-a, VCAM-1 , IL-15, and IL-27
Song et al., Inflamm Res 2011 (MAP Kinase Signaling System) : Black tea polyphenol theaflavin suppresses LPS induced ICAM-1 and VCAM-1 expression via blockage of NF-?B and JNK activation in intestinal epithelial cells ... LPS induced ICAM-1 and VCAM-1 expressions were inhibited by theaflavin ... Bay11-7082 ( a NF-?B inhibitor ) and SP600125 ( a JNK inhibitor ) suppressed the LPS induced ICAM-1 and VCAM-1 mRNA accumulations ... These results indicate that black tea polyphenol theaflavin suppresses LPS induced ICAM-1 and VCAM-1 expressions through blockage of NF-?B and JNK activation in intestinal epithelial cells
Mehla et al., J Ethnopharmacol 2011 : It significantly attenuated LPS induced ICAM-1 and VCAM-1 at the protein and mRNA levels
Fu et al., Mol Hum Reprod 2012 : Our findings show that all progestins significantly suppress endothelial expression of vascular cell adhesion molecule-1 ( VCAM-1 ) and inter-cellular adhesion molecule-1 ( ICAM-1 ) induced by bacterial lypopolysaccharide (LPS)
Wang et al., Zhongguo Zhong Yao Za Zhi 2011 : It has been observed by RT-PCR that HSYA can inhibit the elevation of TNF-alpha, IL-6, ICAM-1 and VCAM-1 mRNA level induced by LPS
van den Elsen et al., Am J Clin Nutr 2011 (Inflammation) : LPS increased the expression of VCAM-1 and the production of several cytokines and growth factors
Liu et al., J Periodontol 2012 (Atherosclerosis...) : However, the mechanism involved in Pg LPS induced VCAM-1 production in endothelial cells remains unclear ... In addition, the p38 MAPK inhibitor ( SB 203580 ) significantly attenuated Pg LPS induced VCAM-1 expression ... Activation of p38 MAPK is at least partially involved in Pg LPS induced VCAM-1 expression in HAECs, which may contribute to the acceleration of atherosclerosis
Qureshi et al., Lipids in health and disease 2011 (Inflammation...) : The microarray DNA analyses, followed by pathway analyses indicated that quercetin or d-tocotrienol inhibit several LPS induced expression of several ageing and pro-inflammatory genes ( IL-1ß, IL-1a, IL-6, TNF-a, IL-12, iNOS, VCAM1 , ICAM1, COX2, IL-1RA, TRAF1 and CD40 )
Joo et al., Gut and liver 2012 : U0126 ( an inhibitor of MEK-1/2 ) suppressed the LPS induced IL-12p40, IL-6, MCP-1, ICAM-1, and VCAM-1 mRNA accumulation in BMMs
Lalu et al., J Cardiovasc Pharmacol 2012 (Inflammation) : LPS increased total content and cell surface expression of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1, whereas proteasome inhibition ameliorated these increases
Shimizu et al., Arterioscler Thromb Vasc Biol 2012 (Disease Models, Animal...) : HGF transgenic mice reduced LPS induced vascular cell adhesion molecule-1 and reactive oxygen species compared with control, accompanied by significant EGFR degradation ... The present study revealed inhibition of LPS induced vascular cell adhesion molecule-1 expression by HGF via the degradation of EGFR
Lee et al., Cell communication and signaling : CCS 2012 : However, the mechanisms underlying VCAM-1 expression induced by LPS are still unclear in human renal mesangial cells ( HRMCs ) ... In HRMCs, LPS induced VCAM-1 expression was, at least in part, mediated through a TLR4/MyD88/ c-Src/NADPH oxidase/ROS/p38 MAPK dependent p300 and ATF2 pathway associated with recruitment of monocyte adhesion to kidney
Liang et al., Arch Pharm Res 2013 : LPS induced endothelial cell adhesion molecules, intercellular adhesion molecular-1 and vascular cell adhesion molecule-1 expressions were also reduced by treatment with SsnB
Cho et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2013 : LPS increased VCAM-1 and ICAM-1 expression ... Ginsenoside Rg2 prevented LPS mediated increase of VCAM-1 and ICAM-1 expression
Hu et al., Am J Chin Med 2013 (Atherosclerosis...) : LPS could promote the expression of VCAM-1 , ICAM-1 and E-SELECTIN
Yang et al., J Immunol 1994 (Sarcoma, Kaposi...) : ICAM-1, VCAM-1 , and E-selectin were all induced by dsRNA ( poly ( I:C ) ), IL-1 beta, TNF-alpha, and LPS in KS cells
Repo et al., Scand J Immunol 1994 : Alkali treated LPS of Yersinia enterocolitica does not induce expression of E-selectin, ICAM-1 or VCAM-1 on endothelial cells but may mediate antibody- and complement dependent cell injury ... Studies of the mechanism underlying the poor augmentation revealed that neither enzymatically deacylated LPS from Escherichia coli J5 ( J5 dLPS ) nor yersinia LPS-OH stimulated expression of endothelial cell adhesion molecules E-selectin, VCAM-1 and ICAM-1, whereas both intact J5 LPS and yersinia LPS were stimulatory
Bereta et al., Cell Immunol 1993 : Flow cytometric analyses revealed that murine microvascular endothelium (MME) in culture constitutively expresses VCAM-1 and that stimulation of MME by TNF, IL-1, or LPS , but not by PMA or staurosporine, strongly increased the surface expression of this cell adhesion molecule
Deisher et al., FEBS Lett 1993 : The role of protein kinase C ( PKC ) in interleukin-1 beta- (II-1 beta)-, tumor necrosis factor-alpha- (TNF-alpha)-, and lipopolysaccharide- (LPS) induced vascular cell adhesion molecule-1 ( VCAM-1 ) expression on human umbilical vein endothelial cells ( HUVEC ) was studied
Pang et al., Clin Exp Immunol 1994 : Finally, both LPS and IL-1 alpha up-regulated ICAM-1 and VCAM-1 gene expression
Sakai et al., Life Sci 1996 : Pretreatment of diclofenac inhibited LPS induced expression of E-selectin, intercellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) in HUVEC, determined by flow cytometry and a cellular enzyme linked immunosorbent assay ( cell-ELISA ) ... The inhibitory activity was concentration dependent between 15.6 and 250 micrograms/ml. Diclofenac also inhibited LPS induced increases in E-selectin, ICAM-1 and VCAM-1 mRNAs, indicating that the action of diclofenac is to inhibit synthesis of these molecules
Sakai et al., Inflamm Res 1996 : Pretreatment of SJC13 inhibited LPS induced expression of E-selectin and vascular cell adhesion molecule-1 ( VCAM-1 ), but not intercellular adhesion molecule-1 ( ICAM-1 ), in HUVEC, determined by flow cytometry and cellular enzyme linked immunosorbent assay ( cell-ELISA ) ... The inhibitory activity was concentration dependent between 62.5 and 1,000 micrograms/ml. SJC13 also selectively inhibited LPS induced increases in E-selectin and VCAM-1 mRNAs, indicating that the action of SJC13 is to inhibit synthesis of these molecules
Kang et al., Shock 1996 : Pretreatment with TGF-beta 1 for 24 h greatly augmented LPS induction of ICAM-1 and VCAM-1 expression, but decreased E-selectin expression
Li et al., Cell Immunol 1997 : Stimulation of IEC-4.1 cells with LPS or TNF-alpha markedly increased the surface expression of both ICAM-1 and VCAM-1 , which correlated with the increased binding of macrophages to the stimulated IEC-4.1 cells
Khachigian et al., Am J Pathol 1997 : Single intraperitoneal administration of N-acetyl cysteine completely suppressed LPS induced VCAM-1 expression on the GMC surface
Lo et al., J Immunol 1998 : FACS analysis reveals that LPG treatment blocked the LPS mediated expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 on endothelial cells and monocyte adhesion without altering the integrity of the endothelial monolayer
Himi et al., Eur Arch Otorhinolaryngol 1998 (Otitis Media) : The present result suggest that functional VCAM-1 induced by LPS is expressed in both middle ear tissue and skin lesions and may play a role in the initial stage of inflammatory response produced
Peng et al., J Immunol 1998 (Inflammation) : Both iNO production and endothelial VCAM-1 expression were induced simultaneously with bacterial LPS and murine-specific IFN-gamma
Kalogeris et al., Am J Physiol 1999 : TNF and LPS stimulated vascular cell adhesion molecule (VCAM)-1 surface expression and adhesion of U-937 monocyte-like cells to HUVECs but not to HUAECs ... These agents also significantly decreased TNF- and LPS stimulated increases in HUVEC surface VCAM-1 ... However, neither TNF or LPS stimulated VCAM-1 expression in HUAECs