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MMP9 — MTA1

Text-mined interactions from Literome

Yan et al., J Biol Chem 2003 : Repression of 92-kDa type IV collagenase expression by MTA1 is mediated through direct interactions with the promoter via a mechanism, which is both dependent on and independent of histone deacetylation ... Enforced MTA1 expression in HT1080 cells reduced basal and 12-myristate 13-acetate induced 92-kDa type IV collagenase ( MMP-9 ) protein/mRNA levels
Kirovski et al., Am J Pathol 2011 (Carcinoma, Hepatocellular...) : MTA induced matrix metalloproteinase ( MMP ) and interleukin-8 transcription in HCC cells in vitro, accompanied by enhanced proliferation and activation of the transcription factor NF?B
Jiang et al., J Exp Clin Cancer Res 2011 (Breast Neoplasms...) : Down-regulation of MTA1 by RNAi approach led to re-expression of ER alpha in ER-negative breast cancer cell lines MDA-MB-231, and reduced protein levels of MMP-9 and CyclinD1, as well as decreased tumor cell invasion and proliferation, more cells were blocked in G0/G1 stage ( P < 0.05 ). However, after inhibiting mRNA levels of MTA1, protein expression of ER alpha, MMP-9, cyclinD1 and the changes of cancer cells invasiveness, proliferation, cells cycle were no statistical difference in ER-positive human breast cancer cell lines MCF-7 ( P > 0.05 )