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CALM3 — NFKB1
Text-mined interactions from Literome
Choi et al., Glia 2001
(Brain Injuries) :
NF-kappaB activation by
N-CAM and cytokines in astrocytes is regulated by multiple protein kinases and redox modulation ... These findings suggest that
activation of
NF-kappaB by
N-CAM and cytokines in astrocytes involves multiple signals that differentially affect NF-kappaB nuclear translocation, DNA binding, and transactivation
Little et al., Proc Natl Acad Sci U S A 2001
:
A short segment within the cytoplasmic domain of the neural cell adhesion molecule ( N-CAM ) is essential for
N-CAM induced
NF-kappa B activity in astrocytes ... Transfection of astrocytes with a construct encompassing the transmembrane region and the cytoplasmic domain of N-CAM ( designated Tm-Cyto, amino acids 685-839 in the full-length molecule ) inhibited this activation up to 40 %, and inhibited
N-CAM induced translocation of
NF-kappaB to the nucleus ...
N-CAM also
activated NF-kappaB in astrocytes from N-CAM knockout mice, presumably through binding to a heterophile ... Overall, these findings define a short segment of the N-CAM cytoplasmic domain that is critical for
N-CAM induced activation of
NF-kappaB and may be important in other N-CAM mediated signaling
Chen et al., Invest Ophthalmol Vis Sci 2005
:
DHA ( 22 : 6n3 ) inhibited cytokine
induced CAM expression through suppression of
NF-kappaB nuclear translocation and upstream I-kappaBalpha phosphorylation and degradation
Waldow et al., Nitric Oxide 2006
:
The TNFalpha induced expression of
CAM was exclusively
dependent on the transcription factor
NFkappaB since the inhibitor of NFkappaB activation, BAY 11-7082, completely blocked the induction ... In summary, a short preincubation of HUVEC with SNAP/Cys results in a persistent suppression of
NFkappaB dependent expression of
CAM
Cirillo et al., J Vasc Res 2007
(Atherosclerosis) :
Superoxide dimutase, Rho A ( Y-27639 ) and
NF-kappaB inhibitors ( pyrrolidine dithiocarbamate ammonium, Bay 11-7082 )
suppressed nicotine effects on
CAM expression
Yang et al., Molecular cancer 2008
(Lymphoma, Mantle-Cell) :
Consistent with a proteasome inhibitor resistant pathway of activation described in mouse B-lymphoma cells ( WEHI231 ) and a breast carcinoma cell line ( MDA-MB-468 ), the bortezomib-resistant
NF-kappaB activity in Rec-1 cells is
inhibited by calcium chelators,
calmodulin inhibitors, and perillyl alcohol, a monoterpene capable of blocking L-type calcium channels
Rajan et al., J Cell Biochem 2008
:
Taken together, our results clearly demonstrate that
NF-kappaB , but not p38, is
critical for TNF-alpha induced
CAM expression
Krushel et al., J Biol Chem 1999
:
These results indicate that
N-CAM homophilic binding at the cell membrane
leads to increased
NF-kappaB binding to DNA and transcriptional activation in both neurons and astrocytes