Gene interactions and pathways from curated databases and text-mining

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EGF — MYC

Text-mined interactions from Literome

Nanba et al., J Cell Physiol 2008 (Fibrosarcoma) : An intermediary role of proHB-EGF shedding in growth factor induced c-Myc gene expression ... Induction of c-Myc expression by EGF or basic FGF is recovered in Hb-egf depleted MEFs by overexpression of wild-type proHB-EGF, but no recovery was observed with an uncleavable mutant of proHB-EGF
Lee et al., Nat Med 2010 (Intestinal Neoplasms...) : MyD88 ( myeloid differentiation primary response gene 88 ) -independent activation of ERK by epidermal growth factor (EGF) increased p-ERK and c-Myc and restored the multiple intestinal neoplasia ( Min ) phenotype in Apc ( min/+ ) /Myd88 ( -/- ) mice
Yoshida et al., Jpn J Cancer Res 1990 (Carcinoma...) : Both EGF and TGF-alpha stimulated EGFR phosphorylation, EGF and TGF-alpha induced FOS, MYC and ERBB-2 oncogene expression
Yang et al., Cell 2012 (Astrocytoma...) : PKM2 dependent histone H3 modifications are instrumental in EGF induced expression of cyclin D1 and c-Myc , tumor cell proliferation, cell-cycle progression, and brain tumorigenesis
Luo et al., J Biol Chem 1995 : Coexpression of recombinant 14.3.3 with recombinant Myc tagged Raf in COS cells does increase substantially the Myc-Raf kinase activity achieved during transient expression, which is attributable primarily to an increased level of Myc-Raf polypeptide, without alteration of Myc-Raf specific activity or the activation that occurs in response to epidermal growth factor or 12-O-tetradecanoylphorbol-13-acetate
Cowlen et al., Biochim Biophys Acta 1993 : We now report the effects of HODEs and prostaglandins on EGF dependent expression of the growth related proto-oncogene c-myc in SHE cells