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CYP2B6 — EGF

Text-mined interactions from Literome

Kietzmann et al., Mol Pharmacol 1999 : Therefore, the influence of arterial ( 16 % O2 ) and venous ( 8 % O2 ) oxygen tension ( pO2 ), and of the heme synthesis inhibitors CoCl2 and desferrioxamine ( DSF ) on PB-dependent CYP2B1 mRNA induction as well as the repression by EGF and, for comparison, by GH, T4, and T3, of the induction under arterial and venous pO2 were investigated in primary rat hepatocytes ... EGF suppressed CYP2B1 mRNA induction by PB only under arterial but not under venous pO2, whereas GH, T4, and T3 inhibited induction under both arterial and venous pO2
Heder et al., Biochem Pharmacol 2001 : Permethrin dependent enhancement of CYP2B1 and CYP3A1 mRNA expression was repressed by the hepatotrophic cytokine epidermal growth factor , which is known to also inhibit PB-dependent induction of CYP2B1
Bauer et al., Mol Pharmacol 2004 : Transcriptional regulation of CYP2B1 induction in primary rat hepatocyte cultures : repression by epidermal growth factor is mediated via a distal enhancer region