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Majewski et al., J Biol Chem 2010
(Colitis...) :
Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 ( PARP-1 ) in the TNF induced inhibition of PHEX expression in osteoblasts ... Our results suggest that NF-?B signaling and PARP-1 enzymatic activity cooperatively contribute to the constitutive and inducible suppression of Phex Daugherty et al., Cancer Chemother Pharmacol 1988
(Leukemia L1210) :
No correlation of PARP activity with cell toxicity was evident ; the activity of PARP was inhibited by HYP ( 42 degrees C ; 1-3 h ) and stimulated by DOX ( 1-10 microM ; 30 min ) ... The HYP induced inhibition of PARP was actually ameliorated by simultaneous exposure to DOX