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CAV1 — TGFB1

Pathways - manually collected, often from reviews:

• NCI Pathway Database ALK1 signaling events: Caveolin-1 (CAV1) → TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CAV1 complex (TGFBR2-TGFBR1-ACVRL1-CAV1-ENG-TGFB1) (modification, collaborate)
  Santibanez et al., Cardiovasc Res 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database ALK1 signaling events: Caveolin-1 (CAV1) → TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB1) (modification, collaborate)
  Santibanez et al., Cardiovasc Res 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database ALK1 signaling events: TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CAV1 complex (TGFBR2-TGFBR1-ACVRL1-CAV1-ENG-TGFB1) → TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB1) (modification, collaborate)
  Santibanez et al., Cardiovasc Res 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database ALK1 signaling events: TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CAV1 complex (TGFBR2-TGFBR1-ACVRL1-CAV1-ENG-TGFB1) → SMAD1-5-8-active (SMAD1/SMAD9/SMAD5) (modification, activates)
  Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Valdimarsdottir et al., BMC cell biology 2006, Santibanez et al., Cardiovasc Res 2008
  Evidence: mutant phenotype, assay
• NCI Pathway Database ALK1 signaling events: TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CAV1 complex (TGFBR2-TGFBR1-ACVRL1-CAV1-ENG-TGFB1) → TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/PPP1CA complex (TGFBR2-TGFBR1-ACVRL1-PPP1CA-ENG-TGFB1) (modification, activates)
  Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Valdimarsdottir et al., BMC cell biology 2006, Santibanez et al., Cardiovasc Res 2008
  Evidence: mutant phenotype, assay
• NCI Pathway Database ALK1 signaling events: TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/CAV1 complex (TGFBR2-TGFBR1-ACVRL1-CAV1-ENG-TGFB1) → SMAD1-5-8 (SMAD1/SMAD9/SMAD5) (modification, activates)
  Oh et al., Proc Natl Acad Sci U S A 2000, Goumans et al., EMBO J 2002, Goumans et al., Mol Cell 2003, Lebrin et al., EMBO J 2004, Blanco et al., J Cell Physiol 2005, Valdimarsdottir et al., BMC cell biology 2006, Santibanez et al., Cardiovasc Res 2008
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Razani et al., J Biol Chem 2001 : Caveolin-1 regulates transforming growth factor ( TGF ) -beta/SMAD signaling through an interaction with the TGF-beta type I receptor
Le Saux et al., J Biol Chem 2008 (Asthma...) : Down-regulation of caveolin-1 , an inhibitor of transforming growth factor-beta signaling, in acute allergen induced airway remodeling
Peng et al., American journal of physiology. Renal physiology 2008 : Furthermore, TGFbeta1 led to association of RhoA and caveolin-1
Del Galdo et al., Arthritis Rheum 2008 (Fibrosis...) : Recent studies have implicated caveolin 1 in the regulation of transforming growth factor beta ( TGFbeta ) downstream signaling
Del Galdo et al., Curr Opin Rheumatol 2008 (Pulmonary Fibrosis...) : Caveolin-1 plays an important role in the regulation of transforming growth factor-beta ( TGF-beta ) signaling owing to its participation in TGF-beta receptor internalization
Ding et al., Zhonghua Jie He He Hu Xi Za Zhi 2010 : [ Expression of caveolin-1 and extracellular matrix induced by transforming growth factor beta1 in human fetal lung fibroblasts ]