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Kim et al., J Bone Miner Res 2009
:
In contrast, inhibition of miR-196a with 2'-O-methyl-antisense RNA increased the protein levels of HOXC8 in treated hASCs and was accompanied by increased proliferation and decreased osteogenic differentiation
Li et al., Cancer Res 2010
(Breast Neoplasms...) :
We found that miR-196 inhibited the expression of transcription factor HOXC8 Mori et al., PLoS Biol 2012
:
Thus, miR-196a induces functional brown adipocytes in WAT through the suppression of Hoxc8 , which functions as a gatekeeper of the inducible brown adipogenesis