◀ Back to NFKB1
NFKB1 — SYK
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Takada et al., J Biol Chem 2003
:
First, H2O2 activated Syk in KBM-5 cells ; second, H2O2 failed to activate NF-kappaB in cells that do not express Syk protein ; third, overexpression of
Syk increased H2O2 induced
NF-kappaB activation ; and fourth, reduction of Syk transcription using small interfering RNA inhibited H2O2 induced NF-kappaB activation
Takada et al., J Immunol 2004
:
Jurkat cells that did not express Syk ( JCaM1, JCaM1/lck ) showed lack of TNF induced
Syk , JNK, p38 MAPK, and p44/p42 MAPK activation, as well as TNF induced IkappaBalpha phosphorylation, IkappaBalpha degradation, and
NF-kappaB activation ... TNF induced
NF-kappaB activation was
enhanced by overexpression of
Syk by Syk-cDNA and suppressed when Syk expression was down-regulated by expression of Syk-small interfering RNA ( siRNA-Syk ) ... The apoptotic effects of TNF were reduced by
up-regulation of
NF-kappaB by
Syk-cDNA , and enhanced by down-regulation of NF-kappaB by siRNA-Syk ... Overall, our results demonstrate that
Syk activation
plays an essential role in TNF induced activation of JNK, p38 MAPK, p44/p42 MAPK,
NF-kappaB , and apoptosis
Ulanova et al., Biochem Biophys Res Commun 2006
:
Inhibition of
Syk down-regulated TNF induced p38 and p44/42 MAPK phosphorylation and nuclear translocation of p65
NF-kappaB
Gallagher et al., J Neurosci 2007
:
CNTF induced SYK phosphorylation is rapidly followed by increased tyrosine phosphorylation of IkappaB-alpha, and blocking
SYK activation or tyrosine phosphorylation of IkappaB-alpha
prevents CNTF induced
NF-kappaB activation and CNTF promoted neurite growth
Oh et al., J Biol Chem 2007
:
Inhibition of the activity of
Syk prior to, concomitant with or shortly following receptor engagement led to the rapid inhibition of receptor mediated tyrosine phosphorylation and
blocked the activation of extracellular signal regulated kinase,
NF-kappaB , and NFAT ... The receptor mediated activation of
NF-kappaB required active
Syk for a relatively short period of time, whereas the activation of NFAT required active kinase for a prolonged ( > 1 h ) period
Bijli et al., J Biol Chem 2008
:
Consistent with this, thrombin induced
NF-kappaB activity and ICAM-1 expression were
prevented by the expression of a kinase-defective mutant or RNA interference knockdown of
Syk ... Analysis of the NF-kappaB pathway showed that
Syk contributes to thrombin induced
NF-kappaB activation by controlling its transactivation potential and that this response is associated with tyrosine phosphorylation of RelA/p65
Bi et al., J Biol Chem 2010
:
The scaffold protein CARD9 plays an essential role in anti-fungus immunity and is implicated in mediating
Dectin-1/Syk induced
NF-kappaB activation in response to Candida albicans infection ... Finally, we find that although both CARD9 and
Syk are
required for Hyphae induced
NF-kappaB activation, they regulate different signaling events in which CARD9 mediates IkappaBalpha kinase ubiquitination, whereas Syk regulates IkappaBalpha kinase phosphorylation