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CFLAR — TNF
Text-mined interactions from Literome
Yeh et al., Immunity 2000
:
NF-kappaB and JNK/SAPK activation is intact in
TNF stimulated
casper-/- cells
Kreuz et al., Mol Cell Biol 2001
:
Treatment of SV80 cells with the proteasome inhibitor N-benzoyloxycarbonyl ( Z ) -Leu-Leu-leucinal ( MG-132 ) or geldanamycin, a drug interfering with tumor necrosis factor (TNF) induced NF-kappaB activation, inhibited
TNF induced upregulation of
cFLIP
Okano et al., Lab Invest 2003
(Carcinoma, Hepatocellular...) :
cFLIP expression was
increased by
TNF-alpha , TRAIL, or vascular endothelial growth factor but decreased by wortmannin, indicating that cFLIP expression is regulated by both the NF-kappaB and phosphatidylinostiol-3 kinase (PI-3)/Akt pathways
Yang et al., Invest Ophthalmol Vis Sci 2005
:
TRAF-1,
c-FLIP , and to a lesser extent c-IAP2 protein levels were
increased by
TNF-alpha in a time dependent manner, whereas c-IAP1, survivin, Bcl-x ( L ), and TRAF-2 protein levels were not influenced by TNF-alpha treatment at any time point tested ... Overexpression of mutant IkappaB blocked
TNF-alpha induced TRAF-1, TRAF-2, c-IAP1, c-IAP2,
c-FLIP , and A1 gene expression and downregulated TRAF-1 protein levels
Ahn et al., Cancer Res 2007
(Skin Neoplasms) :
The
induction of various antiapoptotic gene products ( MMP-9, cyclin D1, COX-2, IAP1, IAP2, Bcl-2,
cFLIP , and XIAP ) by
TNF was also abolished in NQO2-/- cells
O'Gorman et al., Am J Physiol Gastrointest Liver Physiol 2010
:
The
induction of the chemokine interleukin-8 and the antiapoptotic protein
cFLIP by
tumor necrosis factor-alpha were markedly less in HCT116 cells lacking DNMT than in parental cells