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ODC1 — VIP

Text-mined interactions from Literome

Yu et al., Endocrinology 1992 (Adenocarcinoma...) : VIP caused a dose related biphasic change in ODC , with activity increased at 10 pM, maximal ( 5-fold increase ) at 10 nM, and decreased toward basal at 100 nM to 1 microM ... Exposure of cells to 5 mM alpha-difluoromethylornithine blocked both the VIP induced increase in cell number and the VIP induced increase in ODC activity
Gamet et al., Int J Cancer 1991 (Colonic Neoplasms) : The dose-response curve for ODC activation by VIP indicates an EC50 value of 0.078 nM which falls within the range of physiological concentrations for this peptide