◀ Back to IL2
IL2 — WAS
Text-mined interactions from Literome
McCoy et al., J Pharmacol Exp Ther 1999
:
However,
THC did not
affect interleukin-2 production when the macrophages presented a synthetic peptide of the antigen to the T cells, suggesting that the drug may interfere with antigen processing, not peptide presentation
Nakano et al., Proc Soc Exp Biol Med 1992
:
The
effects of delta
9-tetrahydrocannabinol (THC) on lymphocyte proliferation and
interleukin (IL) 2 activity was investigated using adult murine spleen cells stimulated with either the mitogens concanavalin A, phytohemagglutinin, or anti-CD3 antibody ... These results suggest that the dysregulation in immune responses following THC treatment, either suppression or enhancement, may relate to the
effects of
THC on
IL-2 production
Cannon et al., J Immunol 2004
:
Differential
roles for
Wiskott-Aldrich syndrome protein in immune synapse formation and
IL-2 production ... Defects in IL-2 production are observed even under conditions in which immune synapse formation proceeds normally, suggesting that the
role of
WASP in regulating
IL-2 production is independent of its role in immune synapse formation
Sato et al., FEBS J 2005
:
WASP resides in the cytosol as a multifunctional adaptor molecule and
mediates actin polymerization and
interleukin (IL)-2 synthesis in the T-cell receptor ( TCR ) signaling pathway
Konno et al., Int Immunol 2007
:
The notion that WIP promotes WASP function, however, conflicts with evidence that WIP inhibits
WASP mediated actin polymerization and
IL-2 production and suggests a complex regulation of WASP function by WIP
Dong et al., J Biol Chem 2007
(Wiskott-Aldrich Syndrome) :
WASP and its binding partner WIP
play important roles in T cells both in actin polymerization and in
interleukin-2 transcription
Chen et al., J Leukoc Biol 2012
:
THC or CBD suppressed or
enhanced IFN-? and
IL-2 production by mouse splenocytes under optimal or suboptimal stimulation, respectively
Li et al., Eur J Pharmacol 2013
:
Our data demonstrated that
THC significantly
inhibited LPS induced TNF-a,
interleukin-6(IL-6) and nitric oxide ( NO ) production
Régnier-Vigouroux et al., J Immunol 1988
:
Assessment of the Ag-specific THC responses in the presence of either live or formaldehyde prefixed APC indicated the following : 1 ) all THC stringently required Ag processing ; 2 ) in 8 of 16 cases, the simple unfolding of apamin was sufficient to eliminate the need for Ag processing, or even induced increased
THC IL-2 responses ( other cells required further antigenic alterations in addition to unfolding, or rare processing steps dependent on the integrity of the two disulfide bonds ) ; and 3 ) for most THC, the Leu10 and the N terminus arm of apamin were shown to be critical for expression of the epitopes involved in T cell recognition
Condie et al., J Biol Chem 1996
:
Likewise, an inhibition of phorbol 12-myristate 13-acetate ( PMA ) /ionomycin induced
interleukin 2 (IL-2) protein secretion, which correlated to decreased IL-2 gene transcription, was
induced by both cannabinol and
Delta9-THC