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EPHB2 — SYN1
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Kushner et al., J Neurosci 2005
(MAP Kinase Signaling System) :
Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling, we observed that, under normal physiologic conditions in wild-type mice, hippocampus dependent learning stimulated the
ERK dependent phosphorylation of
synapsin I , and MEK ( MAP kinase kinase ) /ERK inhibition selectively decreased the frequency of miniature EPSCs ... By generating transgenic mice expressing a constitutively active form of H-ras ( H-rasG12V ), which is abundantly localized in axon terminals, we were able to increase the
ERK dependent phosphorylation of
synapsin I
Gao et al., Arthritis Res Ther 2006
(Arthritis, Experimental) :
Cultivation of mouse synovial fibroblasts with IL-1beta activates mitogen activated protein kinases, including extra-cellular signal regulated kinase ( Erk ), JNK ( c-Jun N-terminal kinase ), and p38, while only
Erk-specific inhibitor
blocks IL-1beta induced
SYN expression ... Inhibition of
Erk activation
reduces ETS1 phosphorylation and
SYN expression
Giachello et al., J Cell Sci 2010
:
However, the physiological role of
MAPK/Erk dependent
synapsin phosphorylation in regulating synaptic formation and function is poorly understood ... Our findings show that
MAPK/Erk dependent
synapsin phosphorylation has a dual role both in the establishment of functional synaptic connections and their short-term plasticity, indicating that some of the multiple extranuclear functions of MAPK/Erk in neurons can be mediated by the same multifunctional presynaptic target
Iwakura et al., Toxicology 2010
:
A specific
ERK inhibitor, U0126,
reduced the
synapsin I-area without affecting the MAP2-area
Campos et al., Endocrinology 2013
:
Furthermore, fourth ventricle injection of an NMDAR antagonist or the mitogen activated
ERK kinase inhibitor
blocked CCK induced
synapsin I phosphorylation, indicating that synapsin phosphorylation in vagal afferent terminals depends on NMDAR activation and ERK1/2 phosphorylation