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CDKN1A — PML
Text-mined interactions from Literome
Yang et al., Mol Cell Biol Res Commun 1999
:
Transcriptional
activation of the cyclin dependent kinase inhibitor
p21 by
PML/RARalpha ... We showed in this study that
PML/RARalpha increased the transcription of
p21WAF1/CIP1 gene and the activation was further induced by RA treatment ... Transient transfection of
PML/RARalpha in cells
increased the endogenous
p21WAF1/CIP1 protein levels
Son et al., Cancer Lett 2007
(Breast Neoplasms) :
We concluded that PML and all-trans-retinoic acid cause cell death by different pathways :
PML activates ERK1/2, p38 MAPK, and
p21 ; arrests the cell cycle ; and later causes cell death ; and all-trans-retinoic acid activates proteasome function, caspase cleavage, and apoptosis
Yang et al., Cancer Cell 2010
(Neoplasms) :
Furthermore, activated BMK1 notably inhibited
PML dependent activation of
p21
Rokudai et al., Proc Natl Acad Sci U S A 2013
(Leukemia, Promyelocytic, Acute) :
As a result of PML mediated suppression of Akt, the increased
PML-MOZ interaction
enhances p21 expression and induces p53 dependent premature senescence upon forced PML expression