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CDKN1A — PDGFB

Text-mined interactions from Literome

Nathe et al., Arterioscler Thromb Vasc Biol 2002 (Arteriosclerosis) : Our data suggest that IL-1beta may promote SMC proliferation after vascular injury and in atherogenesis by suppression of PDGF-BB induced p21 and p27
Yu et al., J Biol Chem 2003 : PDGF AA activation of alpha-PDGFR or PDGF BB activation of both alpha- and beta-PDGFRs up-regulates expression of p21WAF1/CIP1 , an inhibitor of cell cycle dependent kinases and a downstream mediator of the tumor suppressor gene product p53
Kanasaki et al., Biochem Biophys Res Commun 2006 : Ac-SDKP also up-regulated the PDGF-BB stimulated expression of p21cip1 and suppressed PDGF-BB induced cyclin D1 expression
Pan et al., Zhonghua Xin Xue Guan Bing Za Zhi 2010 : To assess if the modulating effect of platelet derived growth factor (PDGF)-BB on p21 ( WAF1 ) was mediated by upregulating transforming growth factor (TGF)-beta(1) expression in vascular smooth muscle cells ( VSMC ) ... These findings suggested that PDGF-BB inhibited p21 ( WAF1 ) expression in VSMC partially through upregulating TGF-beta(1) expression via PDGF-BB and TGF-beta signalling pathways
Xu et al., Clin Exp Pharmacol Physiol 2011 : In addition, TSG suppressed PDGF-BB induced downregulation of p27 and upregulation of p21 , as well as PDGF-BB induced activation of ERK1/2