Aliouat-Denis et al., Mol Cancer Res 2005
(Breast Neoplasms...) :
However, Chk2 dependent senescence and p21 transcriptional induction also occurred in p53-defective SK-BR-3 ( breast carcinoma ) and HaCaT ( immortalized keratinocyte ) cells
Ullah et al., Genes Dev 2008
:
TS cell mutants revealed that p57 was required to trigger endoreduplication by inhibiting CDK1, while p21 suppressed expression of the checkpoint protein kinase CHK1 , thereby preventing induction of apoptosis
Nguyen et al., Cell cycle (Georgetown, Tex.) 2011
:
These responses are coupled with G2/G1 checkpoint effectors p21 ( CDKN1A ) upregulation, and Chk1 and Chk2 activation