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Xin et al., Am J Physiol Endocrinol Metab 2011
(MAP Kinase Signaling System) :
APPL1 mediates adiponectin stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway ... Interestingly, suppressing APPL1 had no effect on TNFa stimulated p38 MAPK phosphorylation in C ( 2 ) C ( 12 ) myotubes, indicating that the stimulatory effect of APPL1 on p38 MAPK activation is selective
Mora et al., J Cell Sci 2013
:
Therefore, we examined whether Ras1/MAPK is responsible for the high Appl expression