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CTSS — PTBP1
Text-mined interactions from Literome
Kitamura et al., Immunity 2005
:
Importantly,
cathepsin S inhibitors
blocked reduction of MHCII alphabeta dimer, Ii, and H2-DM in the IL-6 treated
DCs
Pierre et al., Cell 1998
:
In immature DCs, inefficient Ii chain cleavage due to low cathepsin S activity leads to the transport of class II-Ii chain complexes to lysosomes, while in mature
DCs , elevated
cathepsin S activity
results in efficient delivery of class II alphabeta dimers to the plasma membrane