Gene interactions and pathways from curated databases and text-mining

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CCNE1 — CDK2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Li et al., Hum Pathol 2001 (Adenocarcinoma...) : From the primary to the liver-metastatic foci, cyclin E apparently decreased, and CDK2 was reduced almost to zero
Lüscher-Firzlaff et al., FEBS Lett 2006 : Regulation of the transcription factor FOXM1c by Cyclin E/CDK2
Deb-Basu et al., Cell cycle (Georgetown, Tex.) 2006 : MYC may induce inappropriate DNA replication through the activation of Cyclin E/CDK2 ... Hence, MYC appears induce inappropriate cell cycle transit, but not mitotic cellular division independent of p27 mediated inhibition of Cyclin E/Cdk2
Wierstra et al., Biochem Biophys Res Commun 2006 : Cyclin E/Cdk2 activates FOXM1c by releasing its transactivation domain from the repression by these two inhibitory domains
Chu et al., Cell 2007 (Breast Neoplasms...) : Src phosphorylated p27 is shown to inhibit cyclin E-Cdk2 poorly in vitro, and Src transfection reduces p27-cyclin E-Cdk2 complexes
Sukhanova et al., BMC developmental biology 2008 : Our data demonstrate that Cyclin E/Cdk2 kinase activity is absolutely required for S phase in SMW, and that Dap is required for the proper cell cycle arrest of cells exiting the SMW
Ghule et al., J Cell Physiol 2009 (Aneuploidy...) : Transcription is controlled at the G1/S phase transition by the Cyclin E/CDK2 mediated induction of p220 ( NPAT ) /HiNF-P complexes at subnuclear domains designated Histone Locus Bodies ( HLBs ) that associate with histone gene clusters ... Transcription is controlled at the G1/S phase transition by the Cyclin E/CDK2 mediated induction of p220 ( NPAT ) /HiNF-P complexes at subnuclear domains designated Histone Locus Bodies ( HLBs ) that associate with histone gene clusters
Zurlo et al., Mol Carcinog 2013 (Colonic Neoplasms...) : Consistently, cyclin D1, cyclin E , CDK2, and CDK4 proteins were reduced and histone H1-associated CDK2 kinase activity inhibited
Hartley et al., Dev Biol 1997 : To investigate the function of cyclin E during the early cycles, cyclin E/Cdk2 kinase activity was specifically inhibited in fertilized eggs by a truncated form of the Xenopus Cdk inhibitor, Xic1 ( Delta34Xic1 )