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EDN1 — PTGS2

Text-mined interactions from Literome

Sugimoto et al., J Am Soc Nephrol 2001 : Endothelin-1 induces cyclooxygenase-2 expression via nuclear factor of activated T-cell transcription factor in glomerular mesangial cells
Wort et al., Mol Pharmacol 2002 (Hypertension, Pulmonary) : The release of endothelin-1 and the transcription of prepro endothelin-1 mRNA were inhibited by the activity of coinduced cyclooxygenase-2 ... Finally, we suggest that these observations may help to explain why patients with pulmonary hypertension experience exacerbations after taking indomethacin and that the newly introduced selective cyclooxygenase-2 inhibitors may increase endothelin-1 production in susceptible patients, leading to vascular remodeling and the development of pulmonary hypertension
Pratt et al., J Biol Chem 2003 : Alterations in subcellular localization of p38 MAPK potentiates endothelin stimulated COX-2 expression in glomerular mesangial cells
Dancu et al., Arterioscler Thromb Vasc Biol 2004 : Asynchronous shear stress and circumferential strain reduces endothelial NO synthase and cyclooxygenase-2 but induces endothelin-1 gene expression in endothelial cells
Spinella et al., J Cardiovasc Pharmacol 2004 (Ovarian Neoplasms) : Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways : evidence for involvement of transactivation of the epidermal growth factor receptor ... Endothelin-1 significantly increases the expression of cyclooxygenase-1 and cyclooxygenase-2 mRNA and protein, the activity of the cyclooxygenase- 2 promoter, and the release of prostaglandin E2 from two ovarian carcinoma cell lines, HEY and OVCA 433 ... In this study we demonstrated that endothelin-1 induced cyclooxygenase-2 and related prostaglandin E2 release were dependent upon the activation of endothelin-A receptor and of multiple mitogen activated protein kinase signal pathways, including extracellular signal regulated kinase 1/2 kinase, p38 mitogen activated protein kinase and the transactivation of the epidermal growth factor receptor
Sugiyama et al., J Cardiovasc Pharmacol 2004 : Endothelin-1 induces cyclooxygenase-2 expression and generation of reactive oxygen species in endothelial cells
Peng et al., Peptides 2008 (Pulmonary Disease, Chronic Obstructive) : Endothelin-1 increases expression of cyclooxygenase-2 and production of interlukin-8 in hunan pulmonary epithelial cells
Lin et al., Cell communication and signaling : CCS 2013 : Up-regulation of COX-2/PGE2 by endothelin-1 via MAPK dependent NF-?B pathway in mouse brain microvascular endothelial cells
Hughes et al., Kidney Int 1995 : Endothelin-1 induction of cyclooxygenase-2 expression in rat mesangial cells
Shimada et al., Eur J Pharmacol 1998 : However, it has not yet been established how endothelin-1 acts on cyclooxygenase 2 expression in macrophages ... In the present study, we examined the effects of endothelin-1 on cyclooxygenase 2 expression and prostaglandin E2 production, and the effects of endothelin ET ( A ) and ET ( B ) receptor antagonists ... Stimulation by endothelin-1 ranging from 10 ( -11 ) to 10 ( -9 ) M time and dose dependently increased the production of prostaglandin E2 and the expression of cyclooxygenase 2 protein without changing that of cyclooxygenase 1 protein, an effect which was inhibited by dexamethasone, nonsteroidal anti-inflammatory drugs and the selective endothelin ET ( B ) receptor antagonist, BQ788 ( N-cis-2,6-dimethylpiperidinocarbonyl-L-gamma-methyl-leucyl-D-L-me thoxycarbonyl-tryptophanyl-D-norleucine )