◀ Back to GSK3B

GSK3B — NEUROD1

Text-mined interactions from Literome

Marcus et al., Mol Cell Neurosci 1998 : The role of GSK3beta in regulating neuronal differentiation in Xenopus laevis ... In the present study we have cloned the Xenopus homolog of the shaggy kinase and show ( 1 ) that GSK3beta is expressed in the right time and place to play a role in primary neurogenesis in Xenopus ; ( 2 ) that overexpression of wild-type GSK3beta leads to a decrease in the number of primary neurons ; ( 3 ) that inhibition of endogenous GSK3beta activity with overexpression of a dominant negative GSK3beta construct leads to an increase in the number of primary neurons ; and ( 4 ) that GSK3beta inhibits the ability of neurogenin and NeuroD to produce ectopic tubulin expression, but does not inhibit the ability of neurogenin to produce ectopic NeuroD ... On the basis of these data we propose that GSK3beta inhibits the function of NeuroD and therefore prevents neuronal differentiation at a relatively late stage in the developmental pathway
Olson et al., Mol Cell Neurosci 1998 (Choristoma...) : GSK3beta , which inhibits NeuroD function in vivo, blocks both Ngn1 induced and NeuroD induced neuronal differentiation , while Notch signaling inhibits only Ngn1 induced neuronal differentiation, confirming that NeuroD is downstream of Ngn1 and insensitive to Notch inhibition