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CD79A — TMED7
Text-mined interactions from Literome
Gesbert et al., J Biol Chem 2000
:
We demonstrate that the decrease of
p27 ( Kip1 ) is directly
due to
BCR/ABL in hematopoietic cells by two different approaches ... The PI3K inhibitor LY-294002 blocks the ability of
BCR/ABL to
induce p27 ( Kip1 ) down-regulation and inhibits BCR/ABL induced entry into S phase ... Overall, these data are consistent with a model in which
BCR/ABL suppresses
p27 ( Kip1 ) protein levels through PI3K/AKT, leading to accelerated entry into S phase
Banerji et al., Oncogene 2001
(Lymphoma, B-Cell...) :
We show that
BCR stimulation of WEHI 231 cells
results in down-regulation of cyclin D2 and up-regulation of
p27 ( Kip1 ), which are associated with pocket protein hypophosphorylation and E2F inactivation
Schuster et al., Blood 2003
:
In contrast, the up-regulation of PU.1 and
p27 ( Kip1 ) by G-CSF was not
affected by
Bcr-Abl
Craxton et al., Eur J Immunol 2007
:
Likewise,
BCR induced
p27 ( Kip1 ) degradation was decreased in Bim KO compared to WT B cells
Richards et al., Eur J Immunol 2009
:
BCR ligation
leads to a more rapid decrease in
p27 ( Kip1 ) levels in gp91(phox) KO B cells