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PTEN — RAD51

Text-mined interactions from Literome

Shen et al., Cell 2007 (Chromosomal Instability) : We show that PTEN acts on chromatin and regulates expression of Rad51 , which reduces the incidence of spontaneous DSBs
Fraser et al., Clin Cancer Res 2012 (Prostatic Neoplasms) : Prostate cancer cell lines and xenografts with known PTEN status ( 22RV1-PTEN ( +/+ ), DU145-PTEN ( +/- ), PC3-PTEN ( -/- ) ) and H1299 and HCT116 cancer cells were used to evaluate how PTEN loss affects RAD51 expression and PARPi sensitivity ... Decreased PTEN expression did not reduce RAD51 expression or clonogenic survival following PARPi among prostate cancer cells that vary in TP53 and PTEN