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BMP4 — CDKN1A

Text-mined interactions from Literome

Gomes et al., Dev Biol 2001 : Msx-2 and p21 mediate the pro-apoptotic but not the anti-proliferative effects of BMP4 on cultured sympathetic neuroblasts ... BMP4 treatment induces expression of the transcription factor Msx-2 and the cyclin dependent kinase inhibitor p21 ( CIP1/WAF1 ) ( p21 )
Carlberg et al., Differentiation 2001 : Infection of C3HIOT1/2 cells with this retroviral construct resulted in an infection efficiency of 90-95 % and was highly effective in converting cells in micromass culture to a chondrocyte phenotype, as assessed by positive Alcian blue staining for extracellular matrix proteoglycans, increased sulfate incorporation, increased expression of the cartilage marker genes collagen type II and aggrecan, and decreased expression of collagen type I. Interestingly, BMP-2 expression in the micromass cultures also induced the expression of the cell cycle inhibitory protein/differentiation factor p21/WAF1 , suggesting its functional involvement in chondrogenesis
Pouliot et al., J Endocrinol 2002 (Breast Neoplasms) : Role of Smad1 and Smad4 proteins in the induction of p21WAF1,Cip1 during bone morphogenetic protein induced growth arrest in human breast cancer cells ... Taken together, these results indicate that the mechanism of BMP induced p21 promoter activation involves BMP receptors and BMP Smads
Israsena et al., J Neurosci Res 2002 : Msx2 and p21 ( CIP1/WAF1 ) mediate the proapoptotic effects of bone morphogenetic protein-4 on ventricular zone progenitor cells ... These observations indicate that msx2 and p21 mediate the proapoptotic effects of BMP4 on VZ progenitor cells and that each gene is necessary but insufficient to promote apoptosis
Tomari et al., Int J Mol Med 2005 (Prostatic Neoplasms) : Furthermore, BMP-2 induced expression of p21 ( WAF1/CIP1 ), a CDK inhibitor
Pardali et al., J Cell Physiol 2005 : Signaling studies with all type I receptors of the TGF-beta superfamily show that BMP receptors induce higher p21 expression than TGF-beta/activin receptors ... Based on the previously known ability of c-Myc to block p21 expression and epithelial growth arrest in response to TGF-beta1, we demonstrate that ectopic c-Myc expression can abrogate Smad mediated p21 induction by all TGF-beta and BMP receptors
Su et al., J Biol Chem 2009 (Carcinoma, Non-Small-Cell Lung...) : We also show that increases of p16(INK4a) and p21 ( WAF1/cip1 ) expression in response to BMP4 were mediated by the Smad signaling pathway
Yin et al., J Virol 2010 : Further, miR-155 inhibits SMAD1 and SMAD5 expression in the lung epithelial cell line A549, it inhibits BMP mediated induction of the cyclin dependent kinase inhibitor p21 , and it reverses BMP mediated cell growth inhibition
Jernvall et al., Development 1998 : The life history of an embryonic signaling center : BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot ... We show that p21 expression is induced by bone morphogenetic protein 4 (BMP-4) in isolated dental epithelia ... Furthermore, we show that the expression of p21 in the enamel knot is followed by Bmp-4 expression, and subsequently by apoptosis of the differentiated enamel knot cells