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APOB — PPARG

Text-mined interactions from Literome

Ares et al., BMC immunology 2002 : LDL and ac-LDL did not activate PPARgamma ... In contrast, oxidized LDL stimulated AP-1 and PPARgamma but inhibited NF-kappaB, indicating that the effects of lipid loading with ac-LDL were not due to oxidation of lipids
Jostarndt et al., Biochem Pharmacol 2004 : Since free oxidized polyunsaturated fatty acids are PPARgamma ligands, we studied the effects of LDL modified by the simultaneous action of sPLA2 and 15-lipoxygenase ( 15LO ) on CD36 expression and PPARgamma activation in monocytic cells ... Our data show that LDL modified with physiologically relevant enzymes stimulates CD36 expression in non differentiated monocytes and that this process involves PPARgamma activation
Zhu et al., Frontiers in bioscience : a journal and virtual library 2005 : Preincubating HUVECs with 15d-PGJ2 attenuated the expression of ICAM-1 and E-selectin in response to ox-LDL, although ox-LDL stimulated the expression of PPARgamma
Lautamäki et al., Rev Diabet Stud 2006 : The effect of PPARgamma-agonism on LDL subclass profile in patients with type 2 diabetes and coronary artery disease
Taketa et al., J Biol Chem 2008 (Atherosclerosis...) : However, the detailed mechanisms of Ox-LDL induced PPARalpha and PPARgamma activation are not fully understood ... In the present study, we investigated the effect of Ox-LDL on PPARalpha and PPARgamma activation in macrophages ... Ox-LDL, but not LDL , induced PPARalpha and PPARgamma activation in a dose dependent manner ... Ox-LDL transiently induced cyclooxygenase-2 (COX-2) mRNA and protein expression, and COX-2 specific inhibition by NS-398 or meloxicam or small interference RNA of COX-2 suppressed Ox-LDL induced PPARalpha and PPARgamma activation ... Ox-LDL induced phosphorylation of ERK1/2 and p38 MAPK, and ERK1/2 specific inhibition abrogated Ox-LDL induced COX-2 expression and PPARalpha and PPARgamma activation , whereas p38 MAPK-specific inhibition had no effect