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ACD — VIP
Text-mined interactions from Literome
Alleaume et al., Neuropeptides 2003
:
We also demonstrated that
VIP induced phosphorylation of the small GTPase
Rap1 in these cancerogenous cells ... Furthermore,
VIP induced the activation of the small GTPase
Rap1 and of a 95 kDa isoform of the serine/threonine kinase B-Raf
Romano et al., J Biol Chem 2003
:
By using pull-down experiments, we show that
VIP and PACAP38 preferentially
activate Rap1 , whereas thyrotropin releasing hormone (TRH) and epidermal growth factor (EGF) mainly activate Ras GTPase
Fernández et al., J Mol Endocrinol 2005
:
Studies in GH4C1 cells, with an expression vector for Rap1 GTPase activating protein ( Rap1 GAP1 ), demonstrated reduced VIP induced MAPK activation, indicating that
VIP dependent activation of the extracellular signal regulated kinase ( ERK ) pathway
requires PKA-Rap1 signaling
Hilairet et al., Neuropeptides 1998
:
In these cells,
VIP induces
Rap 1 phosphorylation and a yet unidentified modification that leads to their acidification