Schick et al., Antisense Res Dev 1995
(Leukemia, Erythroblastic, Acute...) :
Degradation most likely occurred intracellularly, because culture supernatants did not degrade exogenously added serglycin proteoglycan , and the presence of superoxide dismutase and catalase in the culture medium during exposure of the cells to the PS-ODNs did not prevent the degradation
Oh et al., J Rheumatol 1998
:
SIN-1 inhibited proteoglycan synthesis and superoxide dismutase reversed SIN-1 inhibited proteoglycan synthesis, indicating the simultaneous generation of superoxide is essential to inhibit proteoglycan synthesis