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AKT2 — IL3
Text-mined interactions from Literome
Le et al., J Biol Chem 2000
(MAP Kinase Signaling System) :
Moreover, the mutations abolished
IL-3 induced JAK2, STAT, and
AKT activation in the unselected cells, whereas activation of these molecules in IL-3 selected cells was normal
Gu et al., Mol Cell Biol 2000
(Precursor B-Cell Lymphoblastic Leukemia-Lymphoma) :
The majority of cytokine stimulated PI-3K activity associates with Gab2, and inducible expression of a Gab2 mutant unable to bind PI-3K markedly impairs
IL-3 induced
Akt activation and cell growth
Zirngibl et al., Mol Cell Biol 2002
:
Bone marrow derived Fps/Fes-null macrophages showed no defects in granulocyte-macrophage colony stimulating factor-, interleukin 6 (IL-6)-, or
IL-3 induced activation of signal transducer and activator of transcription 3 ( Stat3 ) and Stat5A or LPS induced degradation of I kappa B or activation of p38, Jnk, Erk, or
Akt
Burgess et al., J Neuroimmunol 2003
:
However, only
IL-3 and IGF-I
increase enzymatic activity and phosphorylation of the survival promoting kinase
Akt
Luo et al., Zhonghua Xue Ye Xue Za Zhi 2004
(Leukemia, Myeloid, Acute...) :
In addition, in vitro
Akt phosphorylation was prolonged and
increased following
IL-3 stimulation of this patient 's cells
Luo et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2004
(Leukemia, Myeloid, Acute...) :
In addition,
Akt phosphorylation was prolonged and
increased following
IL-3 stimulation in this patient sample
Okamura et al., Life Sci 2006
:
Contrary to KN-CKIepsilon, WT-CKIepsilon attenuated the
IL-3 induced activation of
Akt with the increase of PTEN activity
Qi et al., J Biol Chem 2006
(Carcinoma, Hepatocellular) :
The PI3K inhibitor, LY294002, blocked
IL-3 stimulated
Akt activity and partially blocked Bim ( EL ) phosphorylation
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008
(Hyperglycemia) :
Resveratrol inhibits high glucose induced
PI3K/Akt/ERK dependent
interleukin-17 expression in primary mouse cardiac fibroblasts
Hidano et al., Int Immunol 2012
:
Biochemical analyses revealed that
IL-3 induced phosphorylation of phospholipase C (PLC) ?2 and
Akt , but not STAT5, was severely reduced in SLP-76-deficient basophils, whereas FceRI cross linking phosphorylation of PLC?2, but not Akt, was abrogated by SLP-76 deficiency, suggesting important differences in the requirement of SLP-76 for Akt activation between FceRI- and IL-3 receptor mediated signaling pathways in basophils
Songyang et al., Proc Natl Acad Sci U S A 1997
:
We find that
Akt kinase activity is rapidly
induced by the cytokine
IL-3 , suggesting a role for Akt in PI 3-kinase dependent signaling in hematopoetic cells
del Peso et al., Science 1997
:
Akt , a survival promoting serine-threonine protein kinase, was
activated by
IL-3 in a PI 3-kinase dependent manner